Niemczyk S, Ludwicka A, Groniowski M, Lewandowski Z, Hasse Z, Wardyn K A
Kliniki Chorób Wewnetrznych, AM w Warszawie.
Pol Arch Med Wewn. 1991 Jan;85(1):12-8.
The effect was studied of oral verapamil administration in two different doses on gentamicin nephrotoxicity. Three groups of Wistar male rats were studied: 1) treated with gentamicin 100 mg/kg b.w. subcutaneously, 2) treated with gentamicin s.c. and verapamil 5 mg/100 ml given in drinking water, 3) treated with gentamicin s.c. and verapamil 20 mg/100 ml. The examinations were performed after 3, 7 and 10 days of gentamicin administration and after 10 days of gentamicin removal. Oral verapamil administration in these doses did not prevent the renal functional and histological damage after gentamicin administration. Renal cortex content of gentamicin was lower only after 3 days of gentamicin administration (statistically significantly) in the verapamil groups.
研究了两种不同剂量口服维拉帕米对庆大霉素肾毒性的影响。研究了三组雄性Wistar大鼠：1）皮下注射100mg/kg体重的庆大霉素；2）皮下注射庆大霉素，饮用水中给予5mg/100ml维拉帕米；3）皮下注射庆大霉素，饮用水中给予20mg/100ml维拉帕米。在给予庆大霉素3天、7天和10天后以及停用庆大霉素10天后进行检查。这些剂量的口服维拉帕米并不能预防庆大霉素给药后的肾功能和组织学损伤。仅在给予庆大霉素3天后，维拉帕米组的肾皮质庆大霉素含量较低（具有统计学显著性）。
