Holly E A, Kelly J W, Shpall S N, Chiu S H
Northern California Cancer Center, Belmont 94002-5030.
J Am Acad Dermatol. 1987 Sep;17(3):459-68. doi: 10.1016/s0190-9622(87)70230-8.
A study of 121 melanoma patients and 139 control subjects from the University of California, San Francisco clinics was conducted among whites to examine the relationship between number of melanocytic nevi and cutaneous melanoma. Nevi that measured 2 mm or more in diameter were counted over the body by a dermatologist and a dermatology fellow. The average number of nondysplastic melanocytic nevi that were 2 mm or greater in diameter was 97 for melanoma patients and 36 for control subjects (p less than 0.001). Relative risks were 1.6 (p = 0.43) for 11 to 25 nevi, 4.4 (p = 0.01) for 26 to 50 nevi, 5.4 (p = 0.008) for 51 to 100 nevi, and 9.8 (p = 0.001) for more than 100 nondysplastic melanocytic nevi. Relative risks were 3.8 (p = 0.001) for 1 to 5 dysplastic nevi and 6.3 (p = 0.003) for 6 or more of these lesions. Report of blistering sunburns or of a previous skin cancer and having red or blond hair at the age of 20 were also independently associated with an increased risk of cutaneous melanoma. If confirmed in larger studies, the results presented on number of nevi and melanoma risk suggest a readily identifiable melanoma-prone group that could be followed to detect early malignant melanoma.
加利福尼亚大学旧金山分校诊所对121名黑色素瘤患者和139名对照受试者进行了一项白人研究，以检查黑素细胞痣数量与皮肤黑色素瘤之间的关系。皮肤科医生和皮肤科住院医师对全身直径2毫米或以上的痣进行计数。直径2毫米或更大的非发育异常性黑素细胞痣的平均数量，黑色素瘤患者为97个，对照受试者为36个（p<0.001）。11至25个痣的相对风险为1.6（p=0.43），26至50个痣的相对风险为4.4（p=0.01），51至100个痣的相对风险为5.4（p=0.008），超过100个非发育异常性黑素细胞痣的相对风险为9.8（p=0.001）。1至5个发育异常痣的相对风险为3.8（p=0.001），6个或更多此类病变的相对风险为6.3（p=0.003）。水泡性晒伤或既往皮肤癌的报告以及20岁时头发为红色或金色也与皮肤黑色素瘤风险增加独立相关。如果在更大规模的研究中得到证实，关于痣数量与黑色素瘤风险的研究结果表明，存在一个易于识别的黑色素瘤易感群体，可对其进行跟踪以检测早期恶性黑色素瘤。
