Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Nuevo León, Mexico.
Institute of Advanced Materials for Sustainable Manufacturing, Tecnologico de Monterrey, Monterrey 64849, Nuevo León, Mexico.
Biosensors (Basel). 2022 Nov 25;12(12):1078. doi: 10.3390/bios12121078.
The synergistic potentialities of innovative materials that include aptamers have opened new paradigms in biosensing platforms for high-throughput monitoring systems. The available nucleobase functional moieties in aptamers offer exclusive features for bioanalytical sensing applications. In this context, compared to various in-practice biological recognition elements, the utilization of aptamers in detection platforms results in an extensive range of advantages in terms of design flexibility, stability, and sensitivity, among other attributes. Thus, the utilization of aptamers-based biosensing platforms is extensively anticipated to meet unaddressed challenges of various in-practice and standard analytical and sensing techniques. Furthermore, the superior characteristics of aptasensors have led to their applicability in the detection of harmful pollutants present in ever-increasing concentrations in different environmental matrices and water bodies, seeking to achieve simple and real-time monitoring. Considering the above-mentioned critiques and notable functional attributes of aptamers, herein, we reviewed aptamers as a fascinating interface to design, develop, and deploy a new generation of monitoring systems to aid modern bioanalytical sensing applications. Moreover, this review aims to summarize the most recent advances in the development and application of aptasensors for the detection of various emerging pollutants (EPs), e.g., pharmaceutical, and personal care products (PPCPs), endocrine-disrupting chemicals (EDCs), pesticides and other agricultural-related compounds, and toxic heavy elements. In addition, the limitations and current challenges are also reviewed, considering the technical constraints and complexity of the environmental samples.
包含适体的创新材料的协同潜力为高通量监测系统的生物传感平台开辟了新的范例。适体中可用的碱基官能团为生物分析传感应用提供了独特的特性。在这种情况下，与各种实际应用的生物识别元件相比，适体在检测平台中的应用在设计灵活性、稳定性和灵敏度等方面具有广泛的优势。因此，基于适体的生物传感平台的应用有望广泛应对各种实际应用和标准分析和传感技术的未解决挑战。此外，适体传感器的优越特性使其能够应用于检测不同环境基质和水体中浓度不断增加的有害污染物，以实现简单和实时监测。考虑到上述批评意见和适体的显著功能特性，本文综述了适体作为设计、开发和部署新一代监测系统以辅助现代生物分析传感应用的迷人界面。此外，本综述旨在总结适体传感器在检测各种新兴污染物 (EPs)，例如药物和个人护理产品 (PPCPs)、内分泌干扰化学物质 (EDCs)、农药和其他与农业相关的化合物以及有毒重金属方面的最新进展。此外，还考虑到环境样品的技术限制和复杂性，对局限性和当前挑战进行了综述。
