Department of Chemistry, Bogazici University, Istanbul 34342, Turkey.
Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Biomolecules. 2022 Dec 5;12(12):1817. doi: 10.3390/biom12121817.
Hyaluronic acid (HA) and chitosan (CHI) are biopolyelectrolytes which are interesting for both the medical and polymer physics communities due to their biocompatibility and semi-flexibility, respectively. In this work, we demonstrate by rheology experiments that the linear viscoelasticity of HA/CHI coacervates depends strongly on the molecular weight of the polymers. Moduli for coacervates were found significantly higher than those of individual HA and CHI physical gels. A remarkable 1.5-fold increase in moduli was noted when catechol-conjugated HA and CHI were used instead. This was attributed to the conversion of coacervates to chemical gels by oxidation of 3,4-dihydroxyphenylalanine (DOPA) groups in HA and CHI to di-DOPA crosslinks. These rheological results put HA/CHI coacervates in the category of strong candidates as injectable tissue scaffolds or medical adhesives.
透明质酸 (HA) 和壳聚糖 (CHI) 是生物高分子电解质，由于其生物相容性和半柔性，分别引起了医学和聚合物物理领域的兴趣。在这项工作中，我们通过流变学实验证明，HA/CHI 共凝聚物的线性粘弹性强烈依赖于聚合物的分子量。共凝聚物的模量明显高于单独的 HA 和 CHI 物理凝胶的模量。当使用儿茶酚共轭的 HA 和 CHI 时，模量增加了 1.5 倍。这归因于通过氧化 HA 和 CHI 中的 3,4-二羟基苯丙氨酸 (DOPA) 基团将共凝聚物转化为化学凝胶，形成二-DOPA 交联。这些流变学结果表明，HA/CHI 共凝聚物是可注射组织支架或医用粘合剂的有力候选物。
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