Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Zhejiang Provincial Key Laboratory for Microbial Biochemistry and Metabolic Engineering, Hangzhou 310058, China.
Biomolecules. 2022 Dec 10;12(12):1848. doi: 10.3390/biom12121848.
Hundreds of proteins work together in microorganisms to coordinate and control normal activity in cells. Their degradation is not only the last step in the cell's lifespan but also the starting point for its recycling. In recent years, protein degradation has been extensively studied in both eukaryotic and prokaryotic organisms. Understanding the degradation process is essential for revealing the complex regulatory network in microorganisms, as well as further artificial reconstructions and applications. This review will discuss several studies on protein quality-control family members Lon, FtsH, ClpP, the proteasome in and a few classical model organisms, mainly focusing on their structure, recognition mechanisms, and metabolic influences.
数百种蛋白质在微生物中协同作用，以协调和控制细胞的正常活动。它们的降解不仅是细胞寿命的最后一步，也是其回收的起点。近年来，蛋白质降解在真核和原核生物中都得到了广泛的研究。了解降解过程对于揭示微生物中复杂的调控网络以及进一步的人工重建和应用至关重要。本文将讨论几种蛋白质质量控制家族成员 Lon、FtsH、ClpP、蛋白酶体在[模式生物]中的研究进展，主要集中在它们的结构、识别机制和代谢影响上。
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