Krysenko Sergii, Wohlleben Wolfgang
Department of Microbiology/Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Cluster of Excellence 'Controlling Microbes to Fight Infections', University of Tübingen, 72076 Tübingen, Germany.
Microorganisms. 2024 Jul 31;12(8):1571. doi: 10.3390/microorganisms12081571.
The natural soil environment of is characterized by variations in the availability of nitrogen, carbon, phosphate and sulfur, leading to complex primary and secondary metabolisms. Their remarkable ability to adapt to fluctuating nutrient conditions is possible through the utilization of a large amount of substrates by diverse intracellular and extracellular enzymes. Thus, fulfill an important ecological role in soil environments, metabolizing the remains of other organisms. In order to survive under changing conditions in their natural habitats, they have the possibility to fall back on specialized enzymes to utilize diverse nutrients and supply compounds from primary metabolism as precursors for secondary metabolite production. We aimed to summarize the knowledge on the C-, N-, P- and S-metabolisms in the genus as a source of building blocks for the production of antibiotics and other relevant compounds.
的自然土壤环境的特点是氮、碳、磷酸盐和硫的可利用性存在差异，导致复杂的初级和次级代谢。它们通过多种细胞内和细胞外酶利用大量底物，从而具有显著的适应营养条件波动的能力。因此，在土壤环境中发挥着重要的生态作用，代谢其他生物的残骸。为了在自然栖息地不断变化的条件下生存，它们有可能依靠专门的酶来利用各种营养物质，并将初级代谢产生的化合物作为次级代谢产物生产的前体。我们旨在总结关于属中碳、氮、磷和硫代谢的知识，作为生产抗生素和其他相关化合物的构建模块来源。
