Chilvers Matthew J, Low Trevor A, Dukelow Sean P
Department of Clinical Neuroscience, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
Brain Sci. 2022 Dec 2;12(12):1651. doi: 10.3390/brainsci12121651.
Proprioceptive deficits are common following stroke, yet the white matter involved in proprioception is poorly understood. Evidence suggests that multiple cortical regions are involved in proprioception, each connected by major white matter tracts, namely: Superior Longitudinal Fasciculus (branches I, II and III), Arcuate Fasciculus and Middle Longitudinal Fasciculus (SLF I, SLF II, SLF III, AF and MdLF respectively). However, direct evidence on the involvement of these tracts in proprioception is lacking. Diffusion imaging was used to investigate the proprioceptive role of the SLF I, SLF II, SLF III, AF and MdLF in 26 participants with stroke, and seven control participants without stroke. Proprioception was assessed using a robotic Arm Position Matching (APM) task, performed in a Kinarm Exoskeleton robotic device. Lesions impacting each tract resulted in worse APM task performance. Lower Fractional Anisotropy (FA) was also associated with poorer APM task performance for the SLF II, III, AF and MdLF. Finally, connectivity data surrounding the cortical regions connected by each tract accurately predicted APM task impairments post-stroke. This study highlights the importance of major cortico-cortical white matter tracts, particularly the SLF III and AF, for accurate proprioception after stroke. It advances our understanding of the white matter tracts responsible for proprioception.
本体感觉缺陷在中风后很常见，但人们对参与本体感觉的白质了解甚少。有证据表明，多个皮质区域参与本体感觉，每个区域都通过主要的白质束相连，即：上纵束（I、II和III分支）、弓状束和中纵束（分别为SLF I、SLF II、SLF III、AF和MdLF）。然而，缺乏关于这些束参与本体感觉的直接证据。本研究使用扩散成像来探究26名中风患者和7名无中风对照参与者中SLF I、SLF II、SLF III、AF和MdLF在本体感觉中的作用。使用Kinarm外骨骼机器人设备进行的手臂位置匹配（APM）任务来评估本体感觉。影响每条束的病变导致APM任务表现更差。较低的分数各向异性（FA）也与SLF II、III、AF和MdLF的APM任务表现较差相关。最后，每条束连接的皮质区域周围的连通性数据准确预测了中风后的APM任务损伤。这项研究强调了主要的皮质-皮质白质束，特别是SLF III和AF，对中风后准确本体感觉的重要性。它增进了我们对负责本体感觉的白质束的理解。
