Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Cells. 2022 Dec 16;11(24):4088. doi: 10.3390/cells11244088.
Periodontitis is significantly associated with the risk of cancers in the lung and the digestive system. Emerging evidence shows a plausible link between periodontitis and several types of brain diseases. However, the association between periodontal infection and glioma remains unclear. In the cultured GL261 glioma cells, lipopolysaccharide (LPS) significantly promoted cell proliferation at concentrations ranging from 10 to 1000 ng/mL. It promoted cell migration at a higher concentration (100 and 1000 ng/mL). Additionally, exposure to 100 ng/mL LPS induced a significant increase in the expression of , , , and , as well as the phosphorylation level of Akt at Ser473. These changes induced by LPS were significantly antagonized by the Akt inhibitor. Furthermore, a total of 48 patients with brain tumors were enrolled to investigate their periodontal status before receiving tumor management. Poor periodontal status [probing depth (PD) ≥ 6 mm and attachment loss (AL) >5 mm] was found in 42.9% (9/21) of patients with glioma, which was significantly higher than that in patients with benign tumors and the relevant data in the 4th National Oral Health Survey in China. The glioma patients with both AL > 5 mm and PD ≥ 6 mm had a higher ki-67 labeling index than those with AL ≤ 5 mm or PD < 6 mm. These findings support the association between periodontal infection and glioma progression.
牙周炎与肺癌和消化系统癌症的风险显著相关。新出现的证据表明，牙周炎与几种类型的脑部疾病之间存在合理的联系。然而，牙周感染与神经胶质瘤之间的关联尚不清楚。在培养的 GL261 神经胶质瘤细胞中，脂多糖（LPS）在 10 至 1000ng/ml 的浓度范围内显著促进细胞增殖。在更高浓度（100 和 1000ng/ml）下促进细胞迁移。此外，暴露于 100ng/ml LPS 诱导 、 、 、 和 Akt 丝氨酸 473 磷酸化水平的显著增加。LPS 诱导的这些变化被 Akt 抑制剂显著拮抗。此外，共纳入 48 例脑肿瘤患者，在接受肿瘤治疗前调查其牙周状况。发现 42.9%（9/21）的神经胶质瘤患者存在牙周状况差（探诊深度[PD]≥6mm 和附着丧失[AL]＞5mm），明显高于良性肿瘤患者和中国第四次全国口腔健康调查的相关数据。AL＞5mm 和 PD≥6mm 的神经胶质瘤患者的 ki-67 标记指数高于 AL≤5mm 或 PD＜6mm 的患者。这些发现支持牙周感染与神经胶质瘤进展之间的关联。
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