线粒体在危重病的免疫反应中起作用。

Mitochondria Drive Immune Responses in Critical Disease.

机构信息

Department of Gastroenterology, University Hospital Heidelberg Medical Clinic, 69120 Heidelberg, Germany.

Center for Inflammation Research, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

出版信息

Cells. 2022 Dec 18;11(24):4113. doi: 10.3390/cells11244113.

DOI:10.3390/cells11244113

PMID:36552877

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9777392/

Abstract

Mitochondria engage in multiple cellular and extracellular signaling pathways ranging from metabolic control, antiviral and antibacterial host defense to the modulation of inflammatory responses following cellular damage and stress. The remarkable contributions of these organelles to innate and adaptive immunity, shape cell phenotype and modulate their functions during infection, after trauma and in the setting of inflammatory disease. We review the latest knowledge of mitochondrial biology and then discuss how these organelles may impact immune cells to drive aberrant immune responses in critical disease.

摘要

线粒体参与多种细胞内和细胞外的信号通路，范围从代谢控制、抗病毒和抗细菌的宿主防御，到细胞损伤和应激后的炎症反应的调节。这些细胞器对先天免疫和适应性免疫的巨大贡献，塑造了细胞表型，并在感染、创伤后和炎症性疾病发生时调节其功能。我们回顾了线粒体生物学的最新知识，然后讨论了这些细胞器如何影响免疫细胞，以在严重疾病中驱动异常的免疫反应。