Illescas María, Peñas Ana, Arenas Joaquín, Martín Miguel A, Ugalde Cristina
Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
Front Cell Dev Biol. 2021 Dec 21;9:795838. doi: 10.3389/fcell.2021.795838. eCollection 2021.
The regulatory role of actin cytoskeleton on mitochondrial function is a growing research field, but the underlying molecular mechanisms remain poorly understood. Specific actin-binding proteins (ABPs), such as Gelsolin, have also been shown to participate in the pathophysiology of mitochondrial OXPHOS disorders through yet to be defined mechanisms. In this mini-review, we will summarize the experimental evidence supporting the fundamental roles of actin cytoskeleton and ABPs on mitochondrial trafficking, dynamics, biogenesis, metabolism and apoptosis, with a particular focus on Gelsolin involvement in mitochondrial disorders. The functional interplay between the actin cytoskeleton, ABPs and mitochondrial membranes for the regulation of cellular homeostasis thus emerges as a new exciting field for future research and therapeutic approaches.
肌动蛋白细胞骨架对线粒体功能的调节作用是一个不断发展的研究领域，但其潜在的分子机制仍知之甚少。特定的肌动蛋白结合蛋白（ABP），如凝溶胶蛋白，也已被证明通过尚未明确的机制参与线粒体氧化磷酸化疾病的病理生理过程。在本综述中，我们将总结支持肌动蛋白细胞骨架和ABP在线粒体运输、动态变化、生物发生、代谢及凋亡中发挥重要作用的实验证据，尤其关注凝溶胶蛋白在 mitochondrial disorders 中的作用。肌动蛋白细胞骨架、ABP与线粒体膜之间在调节细胞稳态方面的功能相互作用，因此成为未来研究和治疗方法的一个新的令人兴奋的领域。
