Ghosh Supratim, Chatterjee Ankita, Maitra Arindam
Biotechnology Research and Innovation Council - National Institute of Biomedical Genomics, Kalyani, India.
Regional Centre for Biotechnology, Faridabad, India.
Int Rev Immunol. 2025;44(4):180-195. doi: 10.1080/08830185.2024.2443420. Epub 2024 Dec 21.
Host immunity helps the body to fight against COVID-19. Single-cell transcriptomics has provided the scope of investigating cellular and molecular underpinnings of host immune response against SARS-CoV-2 infection at high resolution. In this review, we have systematically described the virus-induced dysregulation of relative abundance as well as molecular behavior of each innate and adaptive immune cell type and cell state during COVID-19 infection and for different vaccinations, based on single-cell studies published in last three-four years. Identification and characterization of these disease-associated specific cell populations might help to design better, efficient, and targeted therapeutic avenues.
宿主免疫力有助于身体对抗新冠病毒。单细胞转录组学为高分辨率研究宿主针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的免疫反应的细胞和分子基础提供了范围。在本综述中，我们基于过去三到四年发表的单细胞研究，系统地描述了在新冠病毒感染期间以及不同疫苗接种情况下，每种固有免疫和适应性免疫细胞类型及细胞状态的病毒诱导的相对丰度失调以及分子行为。鉴定和表征这些与疾病相关的特定细胞群体可能有助于设计出更好、更有效且有针对性的治疗途径。
