Akcaalan Serhat, Ozaslan Halil Ibrahim, Caglar Ceyhun, Şimşek Mehmet Emin, Citak Mustafa, Akkaya Mustafa
Kırıkkale Yuksek Ihtısas Hospital, Kırıkkale 71300, Turkey.
Department of Orthopedics and Traumatology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara 06010, Turkey.
Diagnostics (Basel). 2022 Nov 25;12(12):2958. doi: 10.3390/diagnostics12122958.
Periprosthetic joint infection (PJI) is one of the most serious complications after joint arthroplasty. The incidence rate of PJI after total joint replacement is 1-3%. Although there are different guidelines and diagnostic criteria used to diagnose PJI, diagnosing PJI is a highly difficult process for orthopedists. The current Musculoskeletal Infection Society (MSIS) criteria are widely used for the diagnosis of PJI. These criteria include results from blood/synovial fluid tests, physical examination, and histological and microbiological analyses of intra-operative samples. However, there is currently no blood or synovial test that can definitively diagnose PJI. To make a more effective diagnosis of PJI, a large number of studies have explored and continue to investigate biomarkers. This review aims to provide general information about serum and synovial markers used for the diagnosis of PJI that may be used to create a database to guide researchers in new studies.
人工关节周围感染（PJI）是关节置换术后最严重的并发症之一。全关节置换术后PJI的发生率为1%-3%。尽管有不同的指南和诊断标准用于诊断PJI，但对于骨科医生来说，诊断PJI是一个非常困难的过程。目前，肌肉骨骼感染学会（MSIS）的标准被广泛用于PJI的诊断。这些标准包括血液/滑液检测结果、体格检查以及术中样本的组织学和微生物学分析。然而，目前尚无能够明确诊断PJI的血液或滑液检测方法。为了更有效地诊断PJI，大量研究已经进行了探索并仍在继续研究生物标志物。本综述旨在提供有关用于诊断PJI的血清和滑液标志物的一般信息，这些信息可能用于创建一个数据库，以指导研究人员开展新的研究。
