Kapasouri Efthymia Maria, Ioannidis Diomidis C, Cameron Donnie, Vassiliou Vassilios S, Hornberger Michael
Cambridge University Hospitals, Hills Road, Cambridge CB2 0QQ, UK.
Norwich Medical School, University of East Anglia, Norwich NR4 7UQ, UK.
Diagnostics (Basel). 2022 Nov 27;12(12):2967. doi: 10.3390/diagnostics12122967.
We sought to systematically review and meta-analy the role of cerebral blood flow (CBF) in the medial temporal lobe (MTL) using arterial spin labeling magnetic resonance imaging (ASL-MRI) and compare this in patients with Alzheimer's disease (AD), individuals with mild cognitive impairment (MCI), and cognitively normal adults (CN). The prevalence of AD is increasing and leading to high healthcare costs. A potential biomarker that can identify people at risk of developing AD, whilst cognition is normal or only mildly affected, will enable risk-stratification and potential therapeutic interventions in the future. All studies investigated the role of CBF in the MTL and compared this among AD, MCI, and CN participants. A total of 26 studies were included in the systematic review and 11 in the meta-analysis. Three separate meta-analyses were conducted. Four studies compared CBF in the hippocampus of AD compared with the CN group and showed that AD participants had 2.8 mL/min/100 g lower perfusion compared with the CN group. Eight studies compared perfusion in the hippocampus of MCI vs. CN group, which showed no difference. Three studies compared perfusion in the MTL of MCI vs. CN participants and showed no statistically significant differences. CBF measured via ASL-MRI showed impairment in AD compared with the CN group in subregions of the MTL. CBF difference was significant in hippocampus between the AD and CN groups. However, MCI and CN group showed no significant difference in subregions of MTL.
我们旨在利用动脉自旋标记磁共振成像（ASL-MRI）系统评价和荟萃分析大脑中动脉血流（CBF）在内侧颞叶（MTL）中的作用，并在阿尔茨海默病（AD）患者、轻度认知障碍（MCI）个体和认知正常的成年人（CN）中进行比较。AD的患病率正在上升，并导致高昂的医疗成本。一种潜在的生物标志物，能够在认知正常或仅受到轻微影响时识别有患AD风险的人群，将有助于未来的风险分层和潜在的治疗干预。所有研究均调查了CBF在MTL中的作用，并在AD、MCI和CN参与者之间进行了比较。系统评价共纳入26项研究，荟萃分析纳入11项研究。进行了三项独立的荟萃分析。四项研究比较了AD患者与CN组海马区的CBF，结果显示AD参与者的灌注比CN组低2.8 mL/min/100 g。八项研究比较了MCI组与CN组海马区的灌注情况，结果显示无差异。三项研究比较了MCI参与者与CN参与者MTL的灌注情况，结果显示无统计学显著差异。通过ASL-MRI测量的CBF显示，与CN组相比，AD患者MTL亚区域存在损伤。AD组和CN组在海马区的CBF差异显著。然而，MCI组和CN组在MTL亚区域未显示出显著差异。
