Division of Molecular Medicine, Leeds Institute of Medical Research, St James's University Hospital, University of Leeds, Leeds LS9 7TF, UK.
Genes (Basel). 2022 Dec 10;13(12):2332. doi: 10.3390/genes13122332.
CUB and Sushi Multiple Domains 1 (), a tumour suppressor gene, encodes a large membrane-bound protein including a single transmembrane domain. This transmembrane region has a potential tyrosine phosphorylation site, suggesting that CSMD1 is involved in controlling cellular functions. Although the specific mechanisms of action for CSMD1 have not yet been uncovered, it has been linked to a number of processes including development, complement control, neurodevelopment, and cancer progression. In this review, we summarise CSMD1 functions in the cellular processes involved in the complement system, metastasis, and Epithelial mesenchymal transition (EMT) and also in the diseases schizophrenia, Parkinson's disease, and cancer. Clarifying the association between CSMD1 and the aforementioned diseases will contribute to the development of new diagnosis and treatment methods for these diseases. Recent studies in certain cancer types, e.g., gastric cancer, oesophageal cancer, and head and neck squamous cell carcinomas, have indicated the involvement of CSMD1 in response to immunotherapy.
CUB 和 sushi 多结构域蛋白 1 ()，一种肿瘤抑制基因，编码一种包括单个跨膜结构域的大型膜结合蛋白。该跨膜区域具有潜在的酪氨酸磷酸化位点，表明 CSMD1 参与控制细胞功能。尽管 CSMD1 的具体作用机制尚未被揭示，但它与许多过程有关，包括发育、补体控制、神经发育和癌症进展。在这篇综述中，我们总结了 CSMD1 在补体系统、转移和上皮间质转化 (EMT) 涉及的细胞过程中的功能，以及在精神分裂症、帕金森病和癌症等疾病中的功能。阐明 CSMD1 与上述疾病之间的关联将有助于为这些疾病开发新的诊断和治疗方法。最近在某些癌症类型中的研究，例如胃癌、食道癌和头颈部鳞状细胞癌，表明 CSMD1 参与了对免疫疗法的反应。
