俄罗斯芬诺-乌戈尔人群细胞色素 P450 的遗传多态性。
Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia.
机构信息
Federal State Educational Institution of Higher Education, Ufa University of Science and Technology, 450076 Ufa, Russia.
Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences, 450054 Ufa, Russia.
出版信息
Genes (Basel). 2022 Dec 13;13(12):2353. doi: 10.3390/genes13122353.
Cytochrome P450 is an enzyme involved in the metabolism of phase 1 xenobiotics, toxins, endogenous hormones, and drugs, including those used in COVID-19 treatment. Cytochrome p450 genes are linked to the pathogenesis of some multifactorial traits and diseases, such as cancer, particularly prostate cancer, colorectal cancer, breast cancer, and cervical cancer. Genotyping was performed on 540 supposedly healthy individuals of 5 Finno-Permic populations from the territories of the European part of the Russian Federation. There was a statistically significant difference between Veps and most of the studied populations in the rs4986774 locus of the CYP2D6 gene; data on the rs3892097 locus of the CYP2D6 gene shows that Izhemsky Komis are different from the Mordovian and Udmurt populations.
细胞色素 P450 是一种参与 1 相外源性物质、毒素、内源性激素和药物代谢的酶，包括用于 COVID-19 治疗的药物。细胞色素 p450 基因与某些多因素特征和疾病的发病机制有关，如癌症，特别是前列腺癌、结直肠癌、乳腺癌和宫颈癌。对来自俄罗斯联邦欧洲部分领土的 5 个芬诺-佩姆人群体的 540 名据称健康的个体进行了基因分型。在 CYP2D6 基因的 rs4986774 位点，Veps 人与大多数研究人群存在统计学上的显著差异；关于 CYP2D6 基因的 rs3892097 位点的数据表明，Izhemsky Komis 人与莫尔多瓦人和乌德穆尔特人不同。
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