State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
College of Agronomy and Life Sciences and Engineering Research Center for Urban Modern Agriculture of Higher Education in Yunnan Province, Kunming University, Kunming 650214, China.
Int J Mol Sci. 2022 Dec 15;23(24):16005. doi: 10.3390/ijms232416005.
Klebsiella pneumoniae is not only a human and animal opportunistic pathogen, but a food-borne pathogen. Cross-kingdom infection has been focused on since K. pneumoniae was identified as the pathogen of maize, banana, and pomegranate. Although the pathogenicity of K. pneumoniae strains (from ditch water, maize, and human) on plant and mice has been confirmed, there are no reports to explain the molecular mechanisms of the pathogen. This study uncovered the K. pneumoniae KpC4 isolated from maize top rot for the determination of various virulence genes and resistance genes. At least thirteen plant disease-causing genes are found to be involved in the disruption of plant defense. Among them, rcsB is responsible for causing disease in both plants and animals. The novel sequence types provide solid evidence that the pathogen invades plant and has robust ecological adaptability. It is imperative to perform further studies on the verification of these KpC4 genes’ functions to understand the molecular mechanisms involved in plant−pathogen interactions.
肺炎克雷伯氏菌不仅是人和动物的机会性病原体，也是食源性病原体。自从肺炎克雷伯氏菌被确定为玉米、香蕉和石榴的病原体以来，跨领域感染一直是研究的重点。虽然已经证实了来自沟渠水、玉米和人体的肺炎克雷伯氏菌菌株对植物和小鼠的致病性，但目前尚无报道解释该病原体的分子机制。本研究从玉米顶部腐烂中分离出肺炎克雷伯氏菌 KpC4，用于确定各种毒力基因和抗性基因。发现至少十三个植物致病基因参与了植物防御的破坏。其中，rcsB 负责引起植物和动物的疾病。新型序列类型为病原体入侵植物并具有强大的生态适应性提供了确凿的证据。有必要进一步研究这些 KpC4 基因功能的验证，以了解植物-病原体相互作用中涉及的分子机制。
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