Yoo Wanho, Jang Myung Hun, Kim Sang Hun, Yoon Jin A, Jang Hyojin, Kim Soohan, Lee Kwangha
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.
Department of Rehabilitation Medicine, Pusan National University School of Medicine, Busan 49241, Republic of Korea.
J Clin Med. 2022 Dec 13;11(24):7391. doi: 10.3390/jcm11247391.
The main purpose of this study was to develop a model predictive of dysphagia in hospital survivors with severe pneumonia who underwent tracheostomy during their hospital stay. The present study included 175 patients (72% male; mean age, 71.3 years) over 5 years. None of these patients had a history of deglutition disorder before hospital admission. Binary logistic regression analysis was performed to identify factors predicting dysphagia at hospital discharge. Dysphagia scores were calculated from β-coefficients and by assigning points to variables. Of the enrolled patients, 105 (60%) had dysphagia at hospital discharge. Factors prognostic of dysphagia at hospital discharge included being underweight (body mass index < 18.5 kg/m2), non-participation in a dysphagia therapy program, mechanical ventilation ≥ 15 days, age ≥ 74 years, and chronic neurologic diseases. Underweight and non-participation in a dysphagia therapy program were assigned +2 points and the other factors were assigned +1 point. Dysphagia scores showed acceptable discrimination (area under the receiver operating characteristic curve for dysphagia 0.819, 95% confidence interval: 0.754−0.873, p < 0.001) and calibration (Hosmer−Lemeshow chi-square = 9.585, with df 7 and p = 0.213). The developed dysphagia score was predictive of deglutition disorder at hospital discharge in tracheostomized patients with severe pneumonia.
本研究的主要目的是建立一个模型,用于预测在住院期间接受气管切开术的重症肺炎住院幸存者的吞咽困难情况。本研究纳入了5年间的175例患者(男性占72%;平均年龄71.3岁)。这些患者在入院前均无吞咽障碍病史。采用二元逻辑回归分析来确定预测出院时吞咽困难的因素。吞咽困难评分通过β系数计算得出,并为各变量赋值。在纳入的患者中,105例(60%)在出院时存在吞咽困难。出院时吞咽困难的预后因素包括体重过轻(体重指数<18.5kg/m²)、未参加吞咽困难治疗计划、机械通气≥15天、年龄≥74岁以及慢性神经疾病。体重过轻和未参加吞咽困难治疗计划各赋值+2分,其他因素赋值+1分。吞咽困难评分显示出可接受的区分度(吞咽困难的受试者工作特征曲线下面积为0.819,95%置信区间:0.754−0.873,p<0.001)和校准度(Hosmer-Lemeshow卡方值=9.585,自由度为7,p=0.213)。所建立的吞咽困难评分能够预测气管切开的重症肺炎患者出院时的吞咽障碍情况。