Department of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, Italy.
Department of Clinical and Experimental Medicine, University Magna Grecia, 88100 Catanzaro, Italy.
Medicina (Kaunas). 2022 Nov 26;58(12):1728. doi: 10.3390/medicina58121728.
Background and Objectives: Hyperuricemia and liver steatosis are risk factors for cardiovascular diseases and mortality. The use of natural compounds could be a safe and effective alternative to drugs for the treatment of fatty liver and hyperuricemia. Polyphenolic fraction of Citrus Bergamia in association with the extract of Cynara Cardunculus, as nutraceutical, is able to reduce body weight, hepatic steatosis and markers of oxidative stress. Then, we performed a secondary analysis of a double-blind placebo-controlled trial to examine the effects of this nutraceutical on serum uric acid levels in adults with fatty liver. Materials and Methods: The study included 94 individuals with hepatic steatosis. For six weeks, the intervention group was given a nutraceutical (300 mg/day) comprising a Bergamot polyphenol fraction and Cynara Cardunculus extract. The control group received a daily pill of placebo. Serum uric acid, lipids, glucose and anthropometric parameters were assessed at baseline and after 6 weeks. Results: We found a greater reduction in serum uric acid in the participants taking the nutraceutical rather than placebo (−0.1 ± 0.7 mg/dL vs. 0.3 ± 0.7 mg/dL, p = 0.004), and especially in those with moderate/severe hepatic steatosis also after adjustment for confounding variables. In addition, we analysed the two groups according to tertiles of uric acid concentration. Among participants taking the nutraceutical, we found in those with the highest baseline serum uric acid (>5.4 mg/dL) the greater reduction compared to the lowest baseline uric acid (−7.8% vs. +4.9%; adjusted p = 0.04). The stepwise multivariable analysis confirmed the association between the absolute serum uric acid change and nutraceutical treatment (B = −0.43; p = 0.004). Conclusions: A nutraceutical containing bioactive components from bergamot and wild cardoon reduced serum uric acid during 6 weeks in adults with fatty liver. Future investigations are needed to evaluate the efficacy of this nutraceutical in the treatment of hyperuricaemia.
高尿酸血症和肝脂肪变性是心血管疾病和死亡的危险因素。使用天然化合物可能是治疗脂肪肝和高尿酸血症的一种安全有效的药物替代方法。作为一种营养保健品，香柠檬的多酚成分与朝鲜蓟提取物联合使用，可以减轻体重、肝脂肪变性和氧化应激标志物。然后，我们对一项双盲安慰剂对照试验进行了二次分析，以研究这种营养保健品对脂肪肝成年人血清尿酸水平的影响。
该研究纳入了 94 名肝脂肪变性患者。在六周的时间里，干预组每天服用一种包含香柠檬多酚成分和朝鲜蓟提取物的营养保健品（300mg/天）。对照组每天服用安慰剂。在基线和 6 周后评估血清尿酸、血脂、血糖和人体测量参数。
与服用安慰剂相比，服用营养保健品的患者血清尿酸降低更明显（-0.1±0.7mg/dL 与 0.3±0.7mg/dL，p=0.004），尤其是在调整混杂因素后，中重度肝脂肪变性患者的降低更为明显。此外，我们根据尿酸浓度的三分位值对两组进行了分析。在服用营养保健品的患者中，我们发现基线血清尿酸最高（>5.4mg/dL）的患者与基线尿酸最低的患者相比，降低幅度更大（-7.8%与+4.9%；调整后的 p=0.04）。逐步多元分析证实了血清尿酸绝对变化与营养保健品治疗之间的关联（B=-0.43；p=0.004）。
一种含有香柠檬和野生朝鲜蓟生物活性成分的营养保健品可在 6 周内降低脂肪肝成年人的血清尿酸。需要进一步研究评估这种营养保健品在治疗高尿酸血症方面的疗效。
