SARS-CoV-2 突破性感染全景：综述。
Panorama of Breakthrough Infection Caused by SARS-CoV-2: A Review.
机构信息
Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
出版信息
Medicina (Kaunas). 2022 Nov 27;58(12):1733. doi: 10.3390/medicina58121733.
Since the outbreak of the novel coronavirus disease 2019 (COVID-19) in 2019, many countries have successively developed a variety of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, with the continuous spread of SARS-CoV-2, it has evolved several variants; as a result, prevention and control of the pandemic of SARS-CoV-2 has become more important. Among these variants, the Omicron variant has higher transmissibility and immune escape ability and is the main variant causing a large number of COVID-19 breakthrough infection, thus, presenting new challenges to pandemic prevention and control. Hence, we review the biological characteristics of the Omicron variant and discuss the current status and possible mechanism of breakthrough infection caused by the Omicron variant in order to provide insights into the prevention and control of the pandemic of SARS-CoV-2.
自 2019 年新型冠状病毒病（COVID-19）爆发以来，许多国家相继开发了多种针对严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的疫苗。然而，随着 SARS-CoV-2 的不断传播，它已经进化出了几种变体；因此，SARS-CoV-2 的大流行防控变得更加重要。在这些变体中，奥密克戎变体具有更高的传染性和免疫逃逸能力，是导致大量 COVID-19 突破性感染的主要变体，从而给大流行防控带来新的挑战。因此，我们回顾了奥密克戎变体的生物学特征，并讨论了奥密克戎变体引起的突破性感染的现状和可能机制，以期为 SARS-CoV-2 的大流行防控提供思路。
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