Ziegler R J, Stauffer E K
Department of Medical Microbiology and Immunology, School of Medicine, University of Minnesota-Duluth 55812-2487.
J Gen Virol. 1987 Sep;68 ( Pt 9):2501-7. doi: 10.1099/0022-1317-68-9-2501.
Persistent mumps virus infections were established in rat pheochromocytoma (PC-12) and human medulloblastoma (TE-671) continuous cell lines. Significant amounts of infectious virus were produced by the PC-12 cells; infectious virus production by the TE-671 cells was limited. This restricted replication may be due to decreased production of viral envelope glycoproteins by TE-671 cells. The presence of virus changed the distribution of stimulus-evoked electrical responsiveness of both cell lines from responsiveness composed primarily of normal, rapidly rising, all-or-nothing action potentials to one dominated by abnormal, slowly rising, graded responses or by no response at all. Such changes have the potential to disrupt neural integration within the nervous system, and suggest a new mechanism by which persistent virus infections might play a role in chronic neurological and/or mental disease.
在大鼠嗜铬细胞瘤（PC-12）和人髓母细胞瘤（TE-671）连续细胞系中建立了持续性腮腺炎病毒感染。PC-12细胞产生了大量有传染性的病毒；TE-671细胞产生的有传染性病毒有限。这种复制受限可能是由于TE-671细胞产生的病毒包膜糖蛋白减少。病毒的存在改变了两种细胞系刺激诱发的电反应性分布，从主要由正常的、快速上升的、全或无动作电位组成的反应性，变为以异常的、缓慢上升的、分级反应为主或完全无反应的反应性。这种变化有可能破坏神经系统内的神经整合，并提示了一种持续性病毒感染可能在慢性神经和/或精神疾病中起作用的新机制。
