Yamada A, Tsurudome M, Hishiyama M, Ito Y
Virology. 1984 Jun;135(2):299-307. doi: 10.1016/0042-6822(84)90187-9.
After infection with mumps virus, cellular ribonucleic acid synthesis of a murine lymphoma cell line, EL4, was appreciably depressed. The inactivation of viral infectivity by ultraviolet irradiation or the treatment of cells with mouse interferon did not abolish the inhibiting effect, suggesting that virus replication is not required for the depressed RNA synthesis. Envelope glycoproteins isolated from disrupted mumps virus caused inhibition of cellular RNA synthesis. The addition of low concentrations of specific antibody enhanced the inhibitory effect, probably through the formation of aggregates of glycoproteins. On the contrary, the glycoproteins showed no effect on RNA synthesis in the presence of cytochalasin D.
感染腮腺炎病毒后，小鼠淋巴瘤细胞系EL4的细胞核糖核酸合成明显受到抑制。紫外线照射使病毒感染性失活或用小鼠干扰素处理细胞并没有消除这种抑制作用，这表明RNA合成受抑制并不需要病毒复制。从破碎的腮腺炎病毒中分离出的包膜糖蛋白会抑制细胞RNA合成。添加低浓度的特异性抗体可增强抑制作用，可能是通过形成糖蛋白聚集体实现的。相反，在细胞松弛素D存在的情况下，糖蛋白对RNA合成没有影响。
