微连续流条件下金纳米粒子合成的参数研究。

Parametric Study of Gold Nanoparticles Synthesis under Micro-Continuous Flow Conditions.

机构信息

Department of Chemical Engineering, College of Engineering, Jordan University of Science and Technology, Irbid 22110, Jordan.

Department of Chemical Engineering, College of Engineering Technology, University of Doha for Science and Technology, College of Engineering Technology, Doha P.O. Box 24449, Qatar.

出版信息

Molecules. 2022 Dec 7;27(24):8651. doi: 10.3390/molecules27248651.

DOI:10.3390/molecules27248651

PMID:36557787

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9781614/

Abstract

The synthesis of gold nanoparticles (GNPs) using chemical reduction in batch and microreactor methods has been reported. A parametric study of the effect of several parameters on the size of gold nanoparticles was performed in batch synthesis mode using the modified Martin method. The best-obtained conditions were used to synthesize gold nanoparticles using a glass chip microreactor, and the size of the resulting GNPs from both methods was compared. The presence of polyvinyl alcohol (SC) was used as a capping agent, and sodium borohydride (SB) was used as a reducing agent. Several parameters were studied, including HAuCl, SC, SB concentrations, the volumetric ratio of SB to gold precursor, pH, temperature, and mixing speed. Various techniques were used to characterize the resulting nanoparticles, including Atomic Absorbance spectroscopy (AAS), Ultraviolet-visible spectroscopy (UV-Vis), and dynamic light scratching (DLS). Optimum conditions were obtained for the synthesis of gold nanoparticles. Under similar reaction conditions, the microreactor consistently produced smaller nanoparticles in the range of 10.42-11.31 nm with a reaction time of less than 1 min.

摘要

已报道了使用化学还原法在批量和微反应器方法中合成金纳米粒子（GNPs）。使用改进的 Martin 法在批量合成模式下进行了几项参数对金纳米粒子尺寸影响的参数研究。在最佳条件下，使用玻璃芯片微反应器合成金纳米粒子，并比较了这两种方法得到的 GNPs 的尺寸。使用聚乙烯醇（SC）作为封端剂，使用硼氢化钠（SB）作为还原剂。研究了包括 HAuCl、SC、SB 浓度、SB 与金前体的体积比、pH 值、温度和混合速度在内的多个参数。使用原子吸收光谱法（AAS）、紫外可见光谱法（UV-Vis）和动态光散射法（DLS）等多种技术对得到的纳米粒子进行了表征。优化了金纳米粒子的合成条件。在相似的反应条件下，微反应器在不到 1 分钟的反应时间内始终产生 10.42-11.31nm 范围内的更小纳米粒子。