New Benzofuran Oligomers from the Roots of Collected in China.

The chemical constituents of two root samples of DC. collected in Yunnan Province, China, were investigated. Five new oligomeric benzofurans (-), nine new benzofuran/dihydrobenzofuran derivatives, and a new thymol analog were isolated, and their structures were determined using extensive spectroscopic techniques, such as 1D and 2D NMR spectroscopy and DFT calculations of the CD spectra. Most of the new compounds, including oligomeric benzofurans (-), were obtained from only one of the root samples. Furthermore, this is the first example that produces oligomeric benzofurans in this plant. These results imply that diversification of secondary metabolites in is ongoing. Plausible biosynthetic pathways for - are also proposed.