Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, PR China; National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, PR China.
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, PR China.
Fitoterapia. 2020 Oct;146:104674. doi: 10.1016/j.fitote.2020.104674. Epub 2020 Jun 16.
Three new sesquiterpenoids (1-3) and four new benzofuran dimers (+)-4 and (-)-4, (+)-5 and (-)-5, and four known benzofuran dimers (+)-6 and (-)-6, (+)-7 and (-)-7 were isolated from the underground parts of Eupatorium chinense. The enantiomers of racemates (±)-4 ~ (±)-7 were separated by chiral HPLC columns, and their absolute configurations were determined by circular dichroism experiments. The structures of all new compounds were elucidated on the basis of their NMR, and MS data as well as by comparison with literature values. The all of the isolated compounds were tested in vitro for their cytotoxic activities against the Caski, MDA-MB-231 and HepG2 cancer cell lines.
从泽兰属植物地下部分中分离得到三个新的倍半萜（1-3）和四个新的苯并呋喃二聚体（+）-4 和（-）-4、（+）-5 和（-）-5，以及四个已知的苯并呋喃二聚体（+）-6 和（-）-6、（+）-7 和（-）-7。通过手性 HPLC 柱分离出外消旋体（±）-4~（±）-7 的对映异构体，并通过圆二色谱实验确定其绝对构型。根据 NMR 和 MS 数据以及与文献值的比较，确定了所有新化合物的结构。所有分离得到的化合物均在体外进行了细胞毒性活性测试，针对的是宫颈癌细胞系 Caski、MDA-MB-231 和 HepG2。
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