Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-Machi, Nagasaki 852-8521, Japan.
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
Molecules. 2023 Jun 29;28(13):5107. doi: 10.3390/molecules28135107.
Eight samples of leaves were collected at different locations in Yunnan and Sichuan provinces in China, and their chemical constituents were investigated. Thirteen previously undescribed sesquiterpene lactones-seven germacranolides, three eudesmanolides, two guaianolides, and a 2-norelemanolide-were isolated, and their structures were elucidated based on extensive spectroscopic analyses. The major constituents in the six samples from northwestern Yunnan and Sichuan are hiyodorilactones A and B, whereas that in the two samples from the region near Kunming, Yunnan is eupatoriopicrin. These results and previously reported results suggest the presence of locality-dependent intra-specific diversity in the chemical constituents of leaves.
从中国云南和四川的不同地区收集了 8 个 叶样本，并对其化学成分进行了研究。分离得到了 13 个以前未描述的倍半萜内酯——7 个大牻牛儿型内酯、3 个愈创木型内酯、2 个桉烷型内酯和 1 个 2-降埃可内酯，并通过广泛的光谱分析阐明了它们的结构。来自云南和四川西北部的 6 个样本的主要成分是 hiyodorilactones A 和 B，而来自云南昆明附近地区的 2 个样本的主要成分是 eupatoriopicrin。这些结果和以前的报道结果表明， 叶的化学成分存在与地理位置相关的种内多样性。
