Division of Abdominal Surgery, Department of Surgery, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.
Department of Pathology and Immunology, University of Geneva, 1205 Geneva, Switzerland.
Nutrients. 2022 Dec 15;14(24):5340. doi: 10.3390/nu14245340.
Over recent years, non-alcoholic fatty liver disease (NAFLD) has become the most common liver disorder in the developed world, accounting for 20% to 46% of liver abnormalities. Steatosis is the hallmark of NAFLD and is recognized as an important risk factor for complication and death after general surgery, even more so after liver resection. Similarly, liver steatosis also impacts the safety of live liver donation and transplantation. We aim to review surgical outcomes after liver resection for colorectal metastases in patients with steatosis and discuss the most common pre-operative strategies to reduce steatosis. Finally, as illustration, we report the favorable effect of a low-caloric, hyper-protein diet during a two-stage liver resection for colorectal metastases in a patient with severe steatosis.
近年来，非酒精性脂肪性肝病（NAFLD）已成为发达国家最常见的肝脏疾病，占肝脏异常的 20%至 46%。脂肪变性是 NAFLD 的标志，被认为是普外科手术后并发症和死亡的重要危险因素，在肝切除术后更是如此。同样，肝脂肪变性也会影响活体肝捐赠和移植的安全性。我们旨在回顾脂肪变性患者结直肠转移行肝切除术后的手术结果，并讨论减少脂肪变性最常用的术前策略。最后，作为说明，我们报告了在一位严重脂肪变性患者行两阶段肝切除治疗结直肠转移时，低热量高蛋白饮食的良好效果。
