GW4869对口腔念珠菌病小鼠模型侵袭和细胞损伤的促进作用
The Promotional Effect of GW4869 on Invasion and Cellular Damage in a Murine Model of Oral Candidiasis.
作者信息
Zhang Miaomiao, Li Ruowei, Zhou Yifan, Xie Ruiqi, Ma Jingjing, Liu Hong, Qin Yao, Zhao Maomao, Duan Ning, Ye Pei, Wang Wenmei, Wang Xiang
机构信息
Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China.
出版信息
Pathogens. 2022 Dec 12;11(12):1522. doi: 10.3390/pathogens11121522.
() is one of the most common fungi in the human body; it is an opportunistic pathogen and can cause candidiasis. Extracellular vesicles (EVs) derived from the host cells have a potentially protective effect against pathogens and can be developed as vaccine formulations. GW4869 can inhibit the production and release of EVs. Previous studies have indicated that GW4869 can alter the immune and inflammatory responses of the host. However, the effect of GW4869 on infection and the anti- response of the host has not been investigated. We evaluated the effect of GW4869 on invasion, biofilm formation, and cellular damage in a murine model of oral candidiasis. In this study, -infected mice were injected with or without GW4869. The results proven by macroscopic, microscopic, and ultramicroscopic methods showed that GW4869 treatment exacerbated the oral candidiasis of mice, promoted invasion and biofilm formation, and aggravated oral mucosal inflammation and cellular ultrastructural damage. The results are beneficial in the further exploration of the immune mechanism of infection.
（某真菌名称）是人体中最常见的真菌之一；它是一种机会性病原体，可引起念珠菌病。宿主细胞衍生的细胞外囊泡（EVs）对病原体具有潜在的保护作用，可被开发为疫苗制剂。GW4869可抑制细胞外囊泡的产生和释放。先前的研究表明，GW4869可改变宿主的免疫和炎症反应。然而，GW4869对（某真菌名称）感染及宿主抗感染反应的影响尚未得到研究。我们在口腔念珠菌病小鼠模型中评估了GW4869对（某真菌名称）侵袭、生物膜形成和细胞损伤的影响。在本研究中，给感染（某真菌名称）的小鼠注射或不注射GW4869。通过宏观、微观和超微观方法证实的结果表明，GW4869治疗加剧了小鼠的口腔念珠菌病，促进了（某真菌名称）的侵袭和生物膜形成，并加重了口腔黏膜炎症和细胞超微结构损伤。这些结果有助于进一步探索（某真菌名称）感染的免疫机制。
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