Cerri Federico, Giustra Marco, Anadol Yaprak, Tomaino Giulia, Galli Paolo, Labra Massimo, Campone Luca, Colombo Miriam
Department of Earth and Environmental Sciences, University of Milano Bicocca, 20126 Milan, Italy.
Department of Biotechnology and Bioscience, University of Milano Bicocca, 20126 Milan, Italy.
Pharmaceutics. 2022 Dec 14;14(12):2793. doi: 10.3390/pharmaceutics14122793.
Exploring the potential of natural extracts for pharmaceutical applications in the treatment of different diseases is an emerging field of medical research, owing to the tremendous advantages that they can offer. These include compound sustainability due to the natural origin and virtually unlimited availability. In addition, they contribute to promoting the countries in which they are extracted and manufactured. For this reason, wild active compounds derived from plants are attracting increasing interest due to their beneficial properties. Among them, has been recently recognized as a potential source of natural substances with therapeutic activities for anti-cancer treatment. beneficially supplies different chemical compounds, including cyclic triterpenoids, flavonoids, iridoids, naphtaquinones, polyphenols, polysaccharides, and steroids, most of them exhibiting potent antitumor activity. The in vivo and in vitro studies on different models of solid tumors demonstrated its dose-dependent activity. Moreover, the possibility to formulate the extracted molecules in nanoparticles allowed researchers to ameliorate the therapeutic outcome of treatments exploiting improved selectivity toward cancer cells, thus reducing the side effects due to nonspecific spread.
探索天然提取物在治疗不同疾病的药物应用中的潜力是医学研究的一个新兴领域,这得益于它们所能提供的巨大优势。这些优势包括由于天然来源而具有的化合物可持续性以及几乎无限的可用性。此外,它们有助于促进提取物和生产所在的国家的发展。因此,源自植物的野生活性化合物因其有益特性而吸引了越来越多的关注。其中,最近已被公认为是具有抗癌治疗活性的天然物质的潜在来源。它有益地提供了不同的化合物,包括环状三萜类、黄酮类、环烯醚萜类、萘醌类、多酚类、多糖类和甾体类,其中大多数具有强大的抗肿瘤活性。对不同实体瘤模型的体内和体外研究证明了其剂量依赖性活性。此外,将提取的分子制成纳米颗粒的可能性使研究人员能够通过提高对癌细胞的选择性来改善治疗效果,从而减少由于非特异性扩散引起的副作用。