Henry L, Anderson G
Department of Pathology, University of Sheffield Medical School, UK.
J Pathol. 1987 Jul;152(3):149-55. doi: 10.1002/path.1711520303.
One hundred thymus glands were assessed histologically as to their degree of involution. Epithelial cells were demonstrated by an immunoperoxidase method using a monoclonal antibody against cytokeratin. The distribution of these cells was studied in the medulla, the cortico-medullary junction, the cortical parenchyma and the subcapsular cortex. As involution proceeds, the loss of cells from the thymus is almost totally confined to the lymphoid-cell elements. The architecture of the epithelial-cell network remains largely intact although there is extensive collapse of the structure due to the loss of the intervening lymphocytes. Even when involution is apparently complete; sheets of epithelial cells can be demonstrated in the thymic remnant.
对100个胸腺进行了组织学评估，以确定其退化程度。使用抗细胞角蛋白单克隆抗体的免疫过氧化物酶方法显示上皮细胞。研究了这些细胞在髓质、皮质-髓质交界处、皮质实质和被膜下皮质中的分布。随着退化的进行，胸腺细胞的丢失几乎完全局限于淋巴细胞成分。尽管由于中间淋巴细胞的丢失导致结构广泛塌陷，但上皮细胞网络的结构在很大程度上保持完整。即使在退化明显完成时，仍可在胸腺残余物中显示出上皮细胞片。
