Chiesa Enrica, Tottoli Erika Maria, Giglio Alessia, Conti Bice, Rosalia Mariella, Rizzi Laura Giorgia, Dorati Rossella, Genta Ida
Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Directa Plus S.p.a., COMO NexT, Via Cavour, 2, 22074 Lomazzo, Italy.
Polymers (Basel). 2022 Dec 10;14(24):5415. doi: 10.3390/polym14245415.
Graphene is a 2D crystal composed of carbon atoms in a hexagonal arrangement. From their isolation, graphene nanoplatelets (nCD) have revolutionized material science due to their unique properties, and, nowadays, there are countless applications, including drug delivery, biosensors, energy storage, and tissue engineering. Within this work, nCD were combined with PLA, a widely used and clinically relevant thermoplastic polymer, to produce advanced composite texturized electrospun fabric for the next-generation devices. The electrospinning manufacturing process was set-up by virtue of a proper characterization of the composite raw material and its solution. From the morphological point of view, the nCD addition permitted the reduction of the fiber diameter while the texture allowed more aligned fibers. After that, mechanical features of fabrics were tested at RT and upon heating (40 °C, 69 °C), showing the reinforcement action of nCD mainly in the texturized mats at 40 °C. Finally, mats' degradation in simulated physiological fluid was minimal up to 30 d, even if composite mats revealed excellent fluid-handling capability. Moreover, no toxic impurities and degradation products were pointed out during the incubation. This work gains insight on the effects of the combination of composite carbon-based material and texturized fibers to reach highly performing fabrics.
石墨烯是一种由碳原子以六边形排列组成的二维晶体。自石墨烯纳米片（nCD）被分离出来后，因其独特的性质给材料科学带来了变革，如今，其应用数不胜数，包括药物递送、生物传感器、能量存储和组织工程等领域。在这项工作中，nCD与聚乳酸（PLA，一种广泛使用且与临床相关的热塑性聚合物）相结合，以生产用于下一代设备的先进复合纹理化电纺织物。通过对复合原材料及其溶液进行适当表征，建立了静电纺丝制造工艺。从形态学角度来看，添加nCD可使纤维直径减小，而纹理则使纤维排列更整齐。之后，在室温以及加热（40℃、69℃）条件下对织物的机械性能进行了测试，结果表明nCD的增强作用主要体现在40℃时的纹理化毡垫中。最后，在长达30天的时间里，复合毡垫在模拟生理流体中的降解极小，即便复合毡垫展现出了出色的流体处理能力。此外，在孵育过程中未发现有毒杂质和降解产物。这项工作深入研究了复合碳基材料与纹理化纤维相结合对获得高性能织物的影响。
