乳腺脂肪组织衰减作为一种新的代谢风险影像学标志物。
Breast adipose tissue attenuation as a novel imaging biomarker for cardiometabolic risk.
机构信息
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
出版信息
Acta Radiol. 2024 Feb;65(2):167-172. doi: 10.1177/02841851221146267. Epub 2022 Dec 22.
BACKGROUND
Certain adipose tissue depots infer higher cardiometabolic risk than body mass index (BMI).
PURPOSE
To assess breast adipose tissue (BrAT) attenuation as a novel imaging biomarker for cardiometabolic risk.
MATERIAL AND METHODS
We studied 151 women (mean age = 56 ± 1 years) across the weight spectrum. BrAT attenuation, abdominal adipose tissue cross-sectional areas (CSA), and attenuation were quantified using non-contrast computed tomography (CT) scans. Cardiometabolic risk factors were assessed from medical records.
RESULTS
BrAT attenuation was lower in obese women compared to lean women. BrAT attenuation was inversely associated with BMI, waist circumference, abdominal fat CSA, fasting glucose, and triglycerides ( ≤ 0.02), and positively associated with abdominal adipose tissue attenuation ( < 0.001). BrAT attenuation had a sensitivity of 90% but a specificity of only 35% in detecting the metabolic syndrome (area under the curve = 0.63).
CONCLUSION
BrAT attenuation is associated with cardiometabolic risk markers and could serve as an imaging biomarker for opportunistic risk assessment in patients undergoing CT examination of the chest.
背景
某些脂肪组织库暗示心血管代谢风险高于体重指数 (BMI)。
目的
评估乳腺脂肪组织 (BrAT) 衰减作为心血管代谢风险的新型影像学生物标志物。
材料和方法
我们研究了 151 名年龄在 56±1 岁之间的女性，跨越了体重范围。使用非对比计算机断层扫描 (CT) 扫描定量评估 BrAT 衰减、腹部脂肪组织横截面积 (CSA) 和衰减。从病历中评估心血管代谢风险因素。
结果
与瘦女性相比，肥胖女性的 BrAT 衰减较低。BrAT 衰减与 BMI、腰围、腹部脂肪 CSA、空腹血糖和甘油三酯呈负相关（≤0.02），与腹部脂肪组织衰减呈正相关（<0.001）。BrAT 衰减在检测代谢综合征方面的灵敏度为 90%，但特异性仅为 35%（曲线下面积为 0.63）。
结论
BrAT 衰减与心血管代谢风险标志物相关，可作为胸部 CT 检查患者机会性风险评估的影像学生物标志物。
Zotero 插件