Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
J Int Med Res. 2022 Dec;50(12):3000605221138482. doi: 10.1177/03000605221138482.
To evaluate the relationship between the microbiological results of the vitreous humor and those of foreign body specimens in patients with intraocular foreign body (IOFB).
Seventy-one patients with an IOFB were included in this descriptive prospective case series. All patients underwent immediate IOFB removal. Vitreous sampling was performed during vitrectomy. Foreign bodies were placed directly into culture media for microbiological study.
Thirteen (18.3%) patients developed endophthalmitis. The results of microbiological analysis of IOFB and vitreous humor specimens were negative in nine patients and positive in four. Fifty-eight (81.6%) patients with an IOFB had no evidence of endophthalmitis. Among them, seven patients showed positive microbiological results of foreign bodies with no manifestations of endophthalmitis. In five patients, a strain was observed in the culture of the IOFB specimen. Two patients had only positive smear test results of their vitreous humor specimen.
A correlation appears to be present between the microbiological results of the vitreous humor and IOFB specimens in patients with clinical findings of endophthalmitis but not in patients with a pure IOFB without clinical features of endophthalmitis. This may justify early use of intravitreal and intravenous antibiotics before the development of endophthalmitis.
评估眼内异物（IOFB）患者眼内液和异物标本微生物学结果之间的关系。
本研究为描述性前瞻性病例系列研究，纳入 71 例 IOFB 患者。所有患者均行即刻 IOFB 摘除术。在玻璃体切除术中进行眼内液取样。将异物直接置于培养基中进行微生物学研究。
13 例（18.3%）患者发生眼内炎。9 例患者的 IOFB 和眼内液标本微生物分析结果为阴性，4 例为阳性。58 例（81.6%）IOFB 患者无眼内炎证据。其中 7 例异物的微生物学结果阳性而无眼内炎表现，5 例 IOFB 标本培养出菌株，2 例仅玻璃体标本的涂片检查结果阳性。
在有眼内炎临床发现的患者中，眼内液和 IOFB 标本的微生物学结果似乎存在相关性，但在无眼内炎临床特征的单纯 IOFB 患者中则不存在这种相关性。这可能证明在发生眼内炎之前，早期使用玻璃体腔内和静脉内抗生素是合理的。
