Mullin Monica L L, Milne Stephen
Division of Respiratory Medicine, The University of British Columbia.
Centre for Heart Lung Innovation, The University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Curr Opin Pulm Med. 2023 Mar 1;29(2):96-103. doi: 10.1097/MCP.0000000000000935. Epub 2022 Dec 23.
There is biological and epidemiological evidence supporting a role for vitamin D in the respiratory system, and vitamin D deficiency (VDD) may be associated with poor health outcomes in people with chronic obstructive pulmonary disease (COPD). This review summarizes recent findings relevant to the role of vitamin D in COPD.
The prevalence of VDD in people with COPD may be underestimated. Treatment of severe VDD [serum 25(OH)D3 < 10 ng/ml] may reduce the risk of COPD exacerbations. Vitamin D supplementation may also improve functional capacity and quality of life in people with COPD. However, there is no strong evidence that vitamin D supplementation slows the decline in lung function.
Although there are many known associations between vitamin D and COPD outcomes, the causal nature of these associations and the precise benefits of vitamin D supplementation remain unclear. High-quality randomized controlled trials are necessary.
有生物学和流行病学证据支持维生素D在呼吸系统中的作用，维生素D缺乏（VDD）可能与慢性阻塞性肺疾病（COPD）患者的不良健康结局相关。本综述总结了与维生素D在COPD中的作用相关的最新研究结果。
COPD患者中VDD的患病率可能被低估。重度VDD[血清25(OH)D3＜10 ng/ml]的治疗可能会降低COPD急性加重的风险。补充维生素D还可能改善COPD患者的功能能力和生活质量。然而，没有强有力的证据表明补充维生素D能减缓肺功能下降。
尽管维生素D与COPD结局之间存在许多已知关联，但这些关联的因果性质以及补充维生素D的确切益处仍不清楚。高质量的随机对照试验是必要的。
