持续气道正压通气（CPAP）治疗对阻塞性睡眠呼吸暂停合并慢性阻塞性肺疾病重叠综合征患者维生素D状态的影响

Effect of CPAP therapy on vitamin D status in patients with obstructive sleep apnea and chronic obstructive pulmonary disease overlap syndrome.

作者信息

Archontogeorgis Kostas, Voulgaris Athanasios, Chadia Konstantina, Bonelis Konstantinos, Steiropoulos Paschalis

机构信息

Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, 68100, Greece.

MSc Program in Sleep Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

出版信息

Sleep Breath. 2025 Apr 17;29(2):162. doi: 10.1007/s11325-025-03324-0.

DOI:10.1007/s11325-025-03324-0

PMID:40244336

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12006217/

Abstract

PURPOSE

Vitamin D (Vit D) deficiency has been associated with both obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) as well as with their combination, known as overlap syndrome (OS). There is evidence that continuous positive airway pressure (CPAP) may lead to an increase of Vit D levels in OSA patients. However, the effect of CPAP treatment on Vit D levels in OS patients has yet to be determined. The aim of the present study was to investigate the effect of one year of CPAP therapy on Vit D levels in patients with OS.

METHODS

Vit D serum levels were measured in consecutive OS patients at baseline and after one year of CPAP therapy. Compliance with CPAP therapy was assessed by the data retrieved from the CPAP device.

RESULTS

Vit D serum levels were measured in 46 OS patients (43 males). Among participants, 27 had good and 19 poor compliance with CPAP therapy. Results showed that serum Vit D levels increased after 12 months of CPAP therapy from 21.3 ± 8.4 to 23.8 ± 8.7 ng/ml (p = 0.001). Moreover, patients with good CPAP compliance demonstrated higher serum 25(OH)D levels compared to those with poor compliance (25.8 ± 7.6 versus 20.4 ± 9.6 ng/ml, respectively; p = 0.038).

CONCLUSIONS

In conclusion, 12 months of CPAP therapy improved Vit D serum levels in OS patients, more so in compliant patients.

摘要

目的

维生素D（Vit D）缺乏与阻塞性睡眠呼吸暂停（OSA）、慢性阻塞性肺疾病（COPD）及其组合重叠综合征（OS）均相关。有证据表明持续气道正压通气（CPAP）可能会使OSA患者的Vit D水平升高。然而，CPAP治疗对OS患者Vit D水平的影响尚未确定。本研究的目的是调查一年CPAP治疗对OS患者Vit D水平的影响。

方法

对连续入选的OS患者在基线时和CPAP治疗一年后测定血清Vit D水平。通过从CPAP设备获取的数据评估CPAP治疗的依从性。

结果

对46例OS患者（43例男性）测定了血清Vit D水平。在参与者中，27例CPAP治疗依从性良好，19例依从性差。结果显示，CPAP治疗12个月后，血清Vit D水平从21.3±8.4 ng/ml升高至23.8±8.7 ng/ml（p = 0.001）。此外，CPAP依从性良好的患者血清25(OH)D水平高于依从性差的患者（分别为25.8±7.6与20.4±9.6 ng/ml；p = 0.038）。