Long S, Dey S K, Johnson D C
Department of Gynecology & Obstetrics, Ralph L. Smith Research Center, University of Kansas Medical Center, Kansas City 66103.
J Reprod Fertil. 1987 Jul;80(2):649-52. doi: 10.1530/jrf.0.0800649.
An intravenous injection of 2-fluoro-oestradiol simultaneously with an implantation-inducing dose of oestradiol reduced the number of implantation sites in delayed implanting hypophysectomized rats maintained with progesterone. Administration of 2-fluoro-oestradiol 1 h before or after oestradiol had no effect. Furthermore, injection of as much as 500 ng 2-fluoro-oestradiol 48 h before administration of oestradiol failed to have any effect upon implantation, i.e. failure to block implantation was correlated with failure to induce the uterine refractory state. These results suggest that conversion of primary oestrogens to catechol oestrogens could be important for implantation as well as for the induction of the oestrogen refractory state in the uterus.
在给予诱导着床剂量的雌二醇的同时静脉注射2-氟雌二醇，可减少用孕酮维持的延迟着床去垂体大鼠的着床部位数量。在雌二醇之前或之后1小时给予2-氟雌二醇没有效果。此外，在给予雌二醇前48小时注射多达500 ng的2-氟雌二醇对着床没有任何影响，即未能阻断着床与未能诱导子宫不应期状态相关。这些结果表明，初级雌激素转化为儿茶酚雌激素可能对着床以及子宫中雌激素不应期状态的诱导都很重要。
