Tandem C-C/C-N Bond Formation via Rh(III)-Catalyzed α-Fluoroalkenylation and Sequential Annulation of 2-Arylquinazolinones and -Difluorostyrenes.

An efficient method of Rh(III)-catalyzed coupling reaction between 2-arylquinazolinones and -difluorostyrenes has been developed. In this work, two diverse structures of monofluoroalkenes and isoindolo[1,2-]quinazolin-10(12)-one derivatives were respectively synthesized by controlling the amount of additives (Ca(OH) and AgNTf) to achieve controlled stepwise breaking of the C-F bonds of -difluorostyrenes. This reaction has the characteristics of a wide range of substrates and good functional group tolerance. Meanwhile, several control experiments were conducted and a plausible mechanism was proposed.