类风湿关节炎中滑膜衬里细胞增生的可能起源。
Possible origin of synovial lining cell hyperplasia in rheumatoid arthritis.
作者信息
Howat D W
机构信息
Division of Cellular Biology, Kennedy Institute of Rheumatology, London.
出版信息
J R Soc Med. 1987 Aug;80(8):477-8. doi: 10.1177/014107688708000805.
Abstract
A perplexing feature of rheumatoid arthritis is the increase in the number of synovial lining cells with no mitotic activity. This feature has been investigated in the rabbit model. Rabbits with the established condition were injected into the affected joint with tritiated thymidine and killed either up to 24 hours later, or at 3 or 7 days. The location of labelled cells, detected by autoradiography, showed the label predominantly in the stroma in the former, and mainly in the lining cells in the latter, indicating that the lining cells were derived by recruitment from active cells deep in the stroma.
摘要
类风湿性关节炎一个令人费解的特征是滑膜衬里细胞数量增加，且无有丝分裂活性。这一特征已在兔模型中进行了研究。将患有该疾病的兔子的患侧关节注射氚标记的胸腺嘧啶核苷，然后分别在24小时内、3天或7天后处死。通过放射自显影检测标记细胞的位置，结果显示，前者标记主要在基质中，而后者主要在衬里细胞中，这表明衬里细胞是由基质深处的活跃细胞募集而来。
相似文献
1
Possible origin of synovial lining cell hyperplasia in rheumatoid arthritis.类风湿关节炎中滑膜衬里细胞增生的可能起源。
J R Soc Med. 1987 Aug;80(8):477-8. doi: 10.1177/014107688708000805.
2
The origin of the apparent synovial lining cell hyperplasia in rheumatoid arthritis: evidence for a deep stem cell.类风湿关节炎中明显的滑膜衬里细胞增生的起源：深层干细胞的证据。
Br J Exp Pathol. 1987 Apr;68(2):259-66.
3
[A study on origin of the hyperplastic synovial lining cells in rheumatoid arthritis].[类风湿关节炎中增生性滑膜衬里细胞的起源研究]
Zhonghua Wai Ke Za Zhi. 1992 Jun;30(6):367-9, 383.
4
Cell division in the synovial lining in experimental allergic arthritis: proliferation of cells during the development of chronic arthritis.实验性变应性关节炎中滑膜衬里的细胞分裂：慢性关节炎发展过程中细胞的增殖
Ann Rheum Dis. 1982 Jun;41(3):275-81. doi: 10.1136/ard.41.3.275.
5
A comparative quantitative morphometric study of cell apoptosis in synovial membranes in psoriatic, reactive and rheumatoid arthritis.银屑病性关节炎、反应性关节炎和类风湿性关节炎滑膜细胞凋亡的比较定量形态计量学研究
Rheumatology (Oxford). 1999 May;38(5):431-40. doi: 10.1093/rheumatology/38.5.431.
6
Synovial lining cell hyperplasia in rheumatoid arthritis: dogma and fact.类风湿关节炎中的滑膜衬里细胞增生：教条与事实
Ann Rheum Dis. 1988 Apr;47(4):348-9. doi: 10.1136/ard.47.4.348.
7
Phenotypic characterization of 3H-thymidine incorporating cells in rheumatoid arthritis synovial membrane.类风湿性关节炎滑膜中掺入3H-胸腺嘧啶核苷的细胞的表型特征
Rheumatol Int. 1986;6(6):269-71. doi: 10.1007/BF00541318.
8
Reduced synovial membrane macrophage numbers, ELAM-1 expression, and lining layer hyperplasia in psoriatic arthritis as compared with rheumatoid arthritis.与类风湿关节炎相比，银屑病关节炎患者滑膜巨噬细胞数量减少、ELAM-1表达降低以及衬里层增生减少。
Arthritis Rheum. 1993 Jul;36(7):893-900. doi: 10.1002/art.1780360705.
9
Acute non-infectious arthritis of the hip in rheumatoid arthritis: synovial membrane findings.类风湿关节炎中髋关节的急性非感染性关节炎：滑膜表现
Ann Rheum Dis. 1989 Mar;48(3):250-3. doi: 10.1136/ard.48.3.250.
10
Synovial fibroblast hyperplasia in rheumatoid arthritis: clinicopathologic correlations and partial reversal by anti-tumor necrosis factor therapy.类风湿关节炎中的滑膜成纤维细胞增生：临床病理相关性及抗肿瘤坏死因子治疗的部分逆转
Arthritis Rheum. 2011 Sep;63(9):2575-83. doi: 10.1002/art.30433.
引用本文的文献
1
Mast cells in early stages of antigen-induced arthritis in rat knee joints.大鼠膝关节抗原诱导性关节炎早期的肥大细胞
Int J Exp Pathol. 1990 Aug;71(4):455-64.
本文引用的文献
1
The production of arthritis in rabbits by an immunological reaction to fibrin.通过对纤维蛋白的免疫反应在兔子身上诱发关节炎。
Br J Exp Pathol. 1962 Aug;43(4):373-83.
2
Electron microscopy of the human synovial membrane.人体滑膜的电子显微镜检查
J Cell Biol. 1962 Aug;14(2):207-20. doi: 10.1083/jcb.14.2.207.
3
DNA synthesis in human rheumatoid and nonrheumatoid synovial lining.人类类风湿性和非类风湿性滑膜衬里中的DNA合成。
Ann Rheum Dis. 1980 Jun;39(3):241-7. doi: 10.1136/ard.39.3.241.
4
Evidence for cell division in synoviocytes in acutely inflamed rabbit joints.急性炎症兔关节滑膜细胞中细胞分裂的证据。
Ann Rheum Dis. 1981 Apr;40(2):177-81. doi: 10.1136/ard.40.2.177.
5
Cell division in the synovial lining in experimental allergic arthritis: proliferation of cells during the development of chronic arthritis.实验性变应性关节炎中滑膜衬里的细胞分裂：慢性关节炎发展过程中细胞的增殖
Ann Rheum Dis. 1982 Jun;41(3):275-81. doi: 10.1136/ard.41.3.275.
6
Demonstration of bone marrow derived cells in synovial lining by means of giant intracellular granules as genetic markers.通过巨大的细胞内颗粒作为遗传标记物来证明滑膜衬里中的骨髓来源细胞。
Ann Rheum Dis. 1982 Apr;41(2):177-82. doi: 10.1136/ard.41.2.177.
7
The origin of antibody-producing cells in experimental synovitis.
Int Arch Allergy Appl Immunol. 1971;41(1):132-7. doi: 10.1159/000230502.
8
Pathology, pathogenesis, and aetiology of rheumatoid arthritis.类风湿关节炎的病理学、发病机制及病因学
Ann Rheum Dis. 1972 Sep;31(5):412-20. doi: 10.1136/ard.31.5.412.
9
Lysosomal enzymes in synovial membrane in rheumatoid arthritis. Relationship to joint damage.类风湿关节炎滑膜中的溶酶体酶。与关节损伤的关系。
Ann Rheum Dis. 1972 Jul;31(4):265-71. doi: 10.1136/ard.31.4.265.
10
Proliferation of synovial lining cells and fibroblasts.滑膜衬里细胞和成纤维细胞的增殖。
Ann Rheum Dis. 1975 Jun;34(3):219-24. doi: 10.1136/ard.34.3.219.
Zotero 插件