急性炎症兔关节滑膜细胞中细胞分裂的证据。
Evidence for cell division in synoviocytes in acutely inflamed rabbit joints.
作者信息
Henderson B, Glynn L E, Bitensky L, Chayen J
出版信息
Ann Rheum Dis. 1981 Apr;40(2):177-81. doi: 10.1136/ard.40.2.177.
Abstract
DNA synthesis has been measured both by Feulgen cytophotometry, quantified by the DNA synthesis index, and by tritiated thymidine autoradiography, quantified by the labelling index. In the early acute inflammation resulting from the intra-articular challenge of ovalbumin in sensitised rabbits both indices rose considerably, so that at least 1 in 10 synoviocytes was heavily labelled 3 days after challenge. The results are compatible with the concept that even such apparently differentiated synoviocytes are capable of cell division.
摘要
DNA合成已通过Feulgen细胞光度法进行测量，并通过DNA合成指数进行定量，同时也通过氚标记胸腺嘧啶核苷放射自显影法进行测量，并通过标记指数进行定量。在致敏兔关节内注射卵清蛋白引发的早期急性炎症中，这两个指数均显著上升，以至于在注射后3天，至少每10个滑膜细胞中就有1个被大量标记。这些结果与这样一种概念相符，即即使是这种明显分化的滑膜细胞也能够进行细胞分裂。
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