• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新皮层突触记忆痕迹用于远程情境记忆。

Neocortical synaptic engrams for remote contextual memories.

机构信息

Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.

出版信息

Nat Neurosci. 2023 Feb;26(2):259-273. doi: 10.1038/s41593-022-01223-1. Epub 2022 Dec 23.

DOI:10.1038/s41593-022-01223-1
PMID:36564546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9905017/
Abstract

While initial encoding of contextual memories involves the strengthening of hippocampal circuits, these memories progressively mature to stabilized forms in neocortex and become less hippocampus dependent. Although it has been proposed that long-term storage of contextual memories may involve enduring synaptic changes in neocortical circuits, synaptic substrates of remote contextual memories have been elusive. Here we demonstrate that the consolidation of remote contextual fear memories in mice correlated with progressive strengthening of excitatory connections between prefrontal cortical (PFC) engram neurons active during learning and reactivated during remote memory recall, whereas the extinction of remote memories weakened those synapses. This synapse-specific plasticity was CREB-dependent and required sustained hippocampal signals, which the retrosplenial cortex could convey to PFC. Moreover, PFC engram neurons were strongly connected to other PFC neurons recruited during remote memory recall. Our study suggests that progressive and synapse-specific strengthening of PFC circuits can contribute to long-term storage of contextual memories.

摘要

虽然上下文记忆的初始编码涉及海马回路的增强，但这些记忆会逐渐在新皮层中成熟为稳定的形式，并减少对海马体的依赖。尽管有人提出，上下文记忆的长期存储可能涉及新皮层回路中持久的突触变化，但远程上下文记忆的突触基质一直难以捉摸。在这里，我们证明了在小鼠中，远程上下文恐惧记忆的巩固与学习过程中活跃的前额叶皮质（PFC）记忆神经元之间兴奋性连接的逐渐增强以及在远程记忆回忆过程中重新激活相关，而远程记忆的消除则削弱了这些突触。这种特定于突触的可塑性依赖于 CREB，需要持续的海马体信号，而后扣带皮层可以将这些信号传递给 PFC。此外，PFC 记忆神经元与在远程记忆回忆过程中招募的其他 PFC 神经元之间存在强烈的连接。我们的研究表明，PFC 回路的渐进式和特定于突触的增强可能有助于上下文记忆的长期存储。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/70cb7f2cb2aa/41593_2022_1223_Fig18_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/552f7b5bcad5/41593_2022_1223_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/b422c9f0360c/41593_2022_1223_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/ba6da4c09deb/41593_2022_1223_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/5420316c6ebb/41593_2022_1223_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/8c6a5704e982/41593_2022_1223_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/5ab4b2e48bbf/41593_2022_1223_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/bd3e84a2bc00/41593_2022_1223_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/eb9b5bab96cf/41593_2022_1223_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/72990d85ebd5/41593_2022_1223_Fig9_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/d3a3cb381bbd/41593_2022_1223_Fig10_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/b53c09af9d99/41593_2022_1223_Fig11_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/2a3e31d475b9/41593_2022_1223_Fig12_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/d1bc9db1b775/41593_2022_1223_Fig13_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/8a7e06ff2114/41593_2022_1223_Fig14_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/f57ed762448d/41593_2022_1223_Fig15_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/e4665bd528a8/41593_2022_1223_Fig16_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/3dbcecf6e501/41593_2022_1223_Fig17_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/70cb7f2cb2aa/41593_2022_1223_Fig18_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/552f7b5bcad5/41593_2022_1223_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/b422c9f0360c/41593_2022_1223_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/ba6da4c09deb/41593_2022_1223_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/5420316c6ebb/41593_2022_1223_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/8c6a5704e982/41593_2022_1223_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/5ab4b2e48bbf/41593_2022_1223_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/bd3e84a2bc00/41593_2022_1223_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/eb9b5bab96cf/41593_2022_1223_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/72990d85ebd5/41593_2022_1223_Fig9_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/d3a3cb381bbd/41593_2022_1223_Fig10_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/b53c09af9d99/41593_2022_1223_Fig11_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/2a3e31d475b9/41593_2022_1223_Fig12_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/d1bc9db1b775/41593_2022_1223_Fig13_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/8a7e06ff2114/41593_2022_1223_Fig14_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/f57ed762448d/41593_2022_1223_Fig15_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/e4665bd528a8/41593_2022_1223_Fig16_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/3dbcecf6e501/41593_2022_1223_Fig17_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec3/9905017/70cb7f2cb2aa/41593_2022_1223_Fig18_ESM.jpg

相似文献

1
Neocortical synaptic engrams for remote contextual memories.新皮层突触记忆痕迹用于远程情境记忆。
Nat Neurosci. 2023 Feb;26(2):259-273. doi: 10.1038/s41593-022-01223-1. Epub 2022 Dec 23.
2
Engrams and circuits crucial for systems consolidation of a memory.对记忆系统巩固至关重要的记忆痕迹和神经回路。
Science. 2017 Apr 7;356(6333):73-78. doi: 10.1126/science.aam6808.
3
Early remodeling of the neocortex upon episodic memory encoding.情景记忆编码时新皮层的早期重塑。
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11852-7. doi: 10.1073/pnas.1408378111. Epub 2014 Jul 28.
4
Odor modulates the temporal dynamics of fear memory consolidation.气味调节恐惧记忆巩固的时间动态。
Learn Mem. 2020 Mar 16;27(4):150-163. doi: 10.1101/lm.050690.119. Print 2020 Apr.
5
Anterior basolateral amygdala neurons comprise a remote fear memory engram.前基底外侧杏仁核神经元构成了遥远的恐惧记忆的印痕。
Front Neural Circuits. 2023 Apr 27;17:1167825. doi: 10.3389/fncir.2023.1167825. eCollection 2023.
6
Systems consolidation and the content of memory.系统巩固与记忆的内容。
Neurobiol Learn Mem. 2013 Nov;106:365-71. doi: 10.1016/j.nlm.2013.06.001. Epub 2013 Jun 14.
7
A cFos activation map of remote fear memory attenuation.远程恐惧记忆衰减的 cFos 激活图谱。
Psychopharmacology (Berl). 2019 Jan;236(1):369-381. doi: 10.1007/s00213-018-5000-y. Epub 2018 Aug 17.
8
Distinct Contribution of Granular and Agranular Subdivisions of the Retrosplenial Cortex to Remote Contextual Fear Memory Retrieval.隔核皮质的颗粒和无颗粒细分对远距离情景性恐惧记忆检索的独特贡献。
J Neurosci. 2022 Feb 2;42(5):877-893. doi: 10.1523/JNEUROSCI.1303-21.2021. Epub 2021 Dec 7.
9
Memory recall involves a transient break in excitatory-inhibitory balance.记忆回忆涉及兴奋性抑制平衡的短暂中断。
Elife. 2021 Oct 8;10:e70071. doi: 10.7554/eLife.70071.
10
Transient cAMP elevation during systems consolidation enhances remote contextual fear memory.系统巩固过程中短暂的 cAMP 升高增强了远距离情境性恐惧记忆。
Neurobiol Learn Mem. 2020 Mar;169:107171. doi: 10.1016/j.nlm.2020.107171. Epub 2020 Jan 21.

引用本文的文献

1
Progress in spatiotemporal regulation of fear memory: neural circuit mechanisms and implications for PTSD.恐惧记忆的时空调节进展：神经回路机制及其对创伤后应激障碍的影响
Gen Psychiatr. 2025 Aug 26;38(4):e102224. doi: 10.1136/gpsych-2025-102224. eCollection 2025.
2
Experiencing pain: electromagnetic waves, consciousness, and the mind.体验疼痛：电磁波、意识与心灵。
Front Hum Neurosci. 2025 Jul 24;19:1568019. doi: 10.3389/fnhum.2025.1568019. eCollection 2025.
3
Long-Term Memory Engrams From Development to Adulthood.从发育到成年期的长期记忆印迹
Hippocampus. 2025 Sep;35(5):e70032. doi: 10.1002/hipo.70032.
4
Directed cell-type recruitment during consolidation of a remote memory.远程记忆巩固过程中的定向细胞类型募集。
bioRxiv. 2025 Jun 15:2025.06.13.659562. doi: 10.1101/2025.06.13.659562.
5
Sleep need-dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep.丘脑回路的睡眠需求依赖性可塑性促进稳态恢复睡眠。
Science. 2025 Jun 19;388(6753):eadm8203. doi: 10.1126/science.adm8203.
6
Cholinergic modulation of neural networks supports sequential and complementary roles for NREM and REM states in memory consolidation.神经网络的胆碱能调节支持非快速眼动（NREM）和快速眼动（REM）睡眠状态在记忆巩固中的顺序和互补作用。
PLoS Comput Biol. 2025 Jun 17;21(6):e1013097. doi: 10.1371/journal.pcbi.1013097. eCollection 2025 Jun.
7
Hippocampal dorsal CA1: Functional connectivity and role in HCN channelopathies in affective diseases and epilepsy.海马背侧CA1区：情感疾病和癫痫中HCN通道病的功能连接性及作用
IBRO Neurosci Rep. 2025 Apr 4;18:644-656. doi: 10.1016/j.ibneur.2025.03.008. eCollection 2025 Jun.
8
Parabrachial Calca neurons mediate second-order conditioning.臂旁核内钙神经元介导二阶条件反射。
Nat Commun. 2024 Nov 9;15(1):9721. doi: 10.1038/s41467-024-53977-w.
9
The multi-stage plasticity in the aggression circuit underlying the winner effect.胜者效应背后攻击回路中的多阶段可塑性。
Cell. 2024 Nov 27;187(24):6785-6803.e18. doi: 10.1016/j.cell.2024.09.030. Epub 2024 Oct 14.
10
Synaptic rearrangement of NMDA receptors controls memory engram formation and malleability in the cortex.NMDA 受体的突触重排控制皮层中记忆印痕的形成和可塑
Sci Adv. 2024 Aug 30;10(35):eado1148. doi: 10.1126/sciadv.ado1148.