Zeidler Zachary, Yu Abigail L, Seong Moonkyu Patrick, Hundley Rio, DeNardo Laura A
Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Neurosciences Interdepartmental Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
bioRxiv. 2025 Jun 15:2025.06.13.659562. doi: 10.1101/2025.06.13.659562.
Memories are consolidated into a distributed neocortical network for long-term storage. Long-term memory retrieval relies on cells that are active during learning and undergo necessary plasticity. However, remote memory retrieval activates a broader circuit, with learning-activated cells representing only a small subset. What are the rules and cell-types governing memory trace reorganization? We identified a class of prefrontal projection neurons that are gradually recruited to a memory trace through synaptic activity of learning-activated cells. This population, which projects to the temporal association area (TEa), progressively strengthens its encoding of memory-induced behaviors, mirroring increases in TEa activity. Notably, the prefrontal-TEa pathway is required for remote but not recent memory retrieval. Our findings reveal a cell type-specific mechanism underlying memory trace reorganization during consolidation.
记忆被整合到一个分布式新皮质网络中进行长期存储。长期记忆检索依赖于在学习过程中活跃并经历必要可塑性的细胞。然而，远期记忆检索会激活更广泛的回路，其中学习激活的细胞仅占一小部分。控制记忆痕迹重组的规则和细胞类型是什么？我们鉴定出一类前额叶投射神经元，它们通过学习激活细胞的突触活动逐渐被招募到记忆痕迹中。这群投射到颞叶联合区（TEa）的神经元逐渐加强其对记忆诱导行为的编码，这与TEa活动的增加相对应。值得注意的是，前额叶-TEa通路是远期而非近期记忆检索所必需的。我们的研究结果揭示了巩固过程中记忆痕迹重组背后的细胞类型特异性机制。
