关于糖皮质激素信号在衰老过程中对成骨细胞和骨髓脂肪细胞的作用的最新研究进展。
Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging.
机构信息
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
出版信息
Curr Osteoporos Rep. 2023 Feb;21(1):32-44. doi: 10.1007/s11914-022-00772-5. Epub 2022 Dec 24.
Abstract
PURPOSE OF REVIEW
Bone marrow adipose tissue (BMAT) in the skeleton likely plays a variety of physiological and pathophysiological roles that are not yet fully understood. In elucidating the complex relationship between bone and BMAT, glucocorticoids (GCs) are positioned to play a key role, as they have been implicated in the differentiation of bone marrow mesenchymal stem cells (BMSCs) between osteogenic and adipogenic lineages. The purpose of this review is to illuminate aspects of both endogenous and exogenous GC signaling, including the influence of GC receptors, in mechanisms of bone aging including relationships to BMAT.
RECENT FINDINGS
Harmful effects of GCs on bone mass involve several cellular pathways and events that can include BMSC differentiation bias toward adipogenesis and the influence of mature BMAT on bone remodeling through crosstalk. Interestingly, BMAT involvement remains poorly explored in GC-induced osteoporosis and warrants further investigation. This review provides an update on the current understanding of the role of glucocorticoids in the biology of osteoblasts and bone marrow adipocytes (BMAds).
摘要
目的综述
骨骼中的骨髓脂肪组织（BMAT）可能发挥多种生理和病理生理作用，但目前尚未完全了解。在阐明骨与 BMAT 之间复杂的关系时，糖皮质激素（GCs）具有关键作用，因为它们被认为参与了骨髓间充质干细胞（BMSCs）向成骨和成脂谱系的分化。本综述的目的是阐明内源性和外源性 GC 信号的各个方面，包括 GC 受体的影响，以阐明包括与 BMAT 关系在内的骨老化机制。
最近的发现
GC 对骨量的有害影响涉及多种细胞途径和事件，包括 BMSC 向成脂分化的偏倚，以及成熟的 BMAT 通过细胞通讯对骨重塑的影响。有趣的是，GC 诱导性骨质疏松症中 BMAT 的参与仍未得到充分探索，值得进一步研究。本综述提供了糖皮质激素在成骨细胞和骨髓脂肪细胞（BMAds）生物学中作用的最新认识。
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