Department of Dermatology, Zhongshan Hospital (Xiamen branch), Fudan University, Xiamen, China.
Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China.
Australas J Dermatol. 2023 Feb;64(1):126-130. doi: 10.1111/ajd.13963. Epub 2022 Dec 24.
Penicillamine is a chelator that has been used in Wilson's disease, cystinuria, rheumatoid arthritis and heavy metal intoxication. We report a case of a 31-year-old man presented with skin atrophy, purpura and milia on the hips and shoulders after taking penicillamine for 1.5 years. According to literature review, this type of penicillamine-associated cutaneous adverse effect belongs to degenerative dermopathy, which mostly occurs on bony prominences and points of pressure in patients with Wilson's disease or cystinuria. Withdrawal or reduction of drug dose can improve the features of degenerative dermopathy.
青霉胺是一种螯合剂，已用于威尔逊病、胱氨酸尿症、类风湿关节炎和重金属中毒。我们报告了 1 例 31 岁男性患者，在服用青霉胺 1.5 年后，臀部和肩部出现皮肤萎缩、紫癜和粟粒疹。根据文献复习，这种青霉胺相关的皮肤不良反应属于退行性皮肤病，主要发生在威尔逊病或胱氨酸尿症患者的骨突起和受压部位。停药或减少药物剂量可改善退行性皮肤病的特征。
