Zhang Xiao-Fei, Liu Pei-Yi, Zhang Shu-Juan, Zhao Kuai-Le, Zhao Wei-Xin
Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
World J Clin Cases. 2022 Dec 16;10(35):12804-12811. doi: 10.12998/wjcc.v10.i35.12804.
Esophageal squamous cell carcinoma is one of the most common malignant tumors in the digestive system in China and the world. Most patients are diagnosed as locally advanced or advanced stage. Concurrent chemoradiotherapy is the standard treatment for locally advanced esophageal squamous cell carcinoma. This study intends to summarize the evidence-based medical evidence of the treatment principle of locally advanced esophageal squamous cell carcinoma, the selection of radiotherapy dose, the outline of radiotherapy target and the selection of chemotherapy scheme. As a result, the effect of radiotherapy and chemotherapy is equivalent to that of surgery for the radical treatment of esophageal squamous cell carcinoma. In the era of immunization, it is recommended to use involved field irradiation. Fluorouracil plus cisplatin regimen is the standard chemotherapy regimen. FOLFOX regimen and paclitaxel plus fluorouracil regimen are optional concurrent chemotherapy regimens. The toxic and side effects of different chemotherapy regimens are different, which can be selected according to the actual situation of patients.
食管鳞状细胞癌是中国和世界消化系统中最常见的恶性肿瘤之一。大多数患者被诊断为局部晚期或晚期。同步放化疗是局部晚期食管鳞状细胞癌的标准治疗方法。本研究旨在总结局部晚期食管鳞状细胞癌治疗原则、放疗剂量选择、放疗靶区勾画及化疗方案选择的循证医学证据。结果表明，放化疗对食管鳞状细胞癌根治的效果与手术相当。在免疫治疗时代，建议采用累及野照射。氟尿嘧啶加顺铂方案是标准化疗方案。FOLFOX方案和紫杉醇加氟尿嘧啶方案是可选的同步化疗方案。不同化疗方案的毒副作用不同，可根据患者实际情况选择。
