Vempati Roopeessh, Samuganathan Periyaiyadever, Raghavan Prithvi, Rajpal Shreyaa, Guralwar Chinmay, Padamati Bhavani, Tango Tamara, Sahu Sweta, Bingi Thrilok Chander
Internal Medicine, Gandhi Medical College and Hospital, Hyderabad, IND.
General Practice, Impian Care Clinic, Kuala Lumpur, MYS.
Cureus. 2022 Nov 22;14(11):e31772. doi: 10.7759/cureus.31772. eCollection 2022 Nov.
Central nervous system tuberculosis (CNS-TB) is rarely suspected in pregnancy because its clinical presentation may masquerade other common conditions in pregnancy, such as eclampsia. In high tuberculosis endemic areas, CNS-TB should be suspected with a high degree of suspicion among unimmunized and immunocompromised individuals. We hereby report a case of a 32-year-old pregnant woman conceived by in vitro fertilization due to tubal blockage causing infertility, probably due to chronic infection, who presented with a history of multiple seizure episodes without a history of similar complaints outside this pregnancy. Obstetric examination revealed a gravid uterus larger than the corresponding gestational age, and an antenatal scan confirmed dichorionic diamniotic twins with the first twin in the breech and the second twin in the cephalic presentation. Magnetic resonance imaging of the brain revealed multiple nodular lesions of varying sizes that were isointense on T1-weighted imaging and hypointense on T2-weighted imaging in multiple regions of the brain, which suggest tuberculomas. A preterm cesarean section was performed at 31 weeks gestational age due to preterm rupture of membranes. We report this case to enlighten the physicians in diagnosing seizures causing intracranial tuberculoma in pregnant women and utilizing the role of imaging in diagnosis.
中枢神经系统结核(CNS-TB)在孕期很少被怀疑,因为其临床表现可能会伪装成孕期其他常见病症,如子痫。在结核病高发地区,对于未接种疫苗和免疫功能低下的个体,应高度怀疑中枢神经系统结核。我们在此报告一例32岁的孕妇,因输卵管堵塞导致不孕,通过体外受精受孕,可能是由于慢性感染,该孕妇有多次癫痫发作史,此次怀孕之外无类似病史。产科检查发现子宫大小大于相应孕周,产前超声检查证实为双绒毛膜双羊膜囊双胎,第一胎儿臀位,第二胎儿头位。脑部磁共振成像显示脑内多个区域有大小不等的结节状病变,在T1加权成像上呈等信号,在T2加权成像上呈低信号,提示结核瘤。因胎膜早破,在孕31周时进行了早产剖宫产。我们报告此病例是为了让医生们了解在诊断孕妇颅内结核瘤所致癫痫发作方面的情况,并认识到影像学在诊断中的作用。