Department of Public Health, Medical College of Qinghai University, Xining, China.
Department of Infection Disease, Qinghai Center for Disease Prevention and Control, Xining, China.
Front Immunol. 2022 Dec 7;13:1011700. doi: 10.3389/fimmu.2022.1011700. eCollection 2022.
The present study was performed to evaluate the association of WNT signaling pathway genes variants with pulmonary tuberculosis (PTB) risk in Chinese Han population. Our study subjects were composed of 452 PTB patients and 465 normal controls, and seventeen SNPs of seven genes in WNT signaling pathway (, , , , , ) were genotyped by SNPscan technique. We found no significant relationship of rs10088390, rs4736958, rs3242, rs752107, rs3121310, rs2293303, rs1798802, rs4135385, rs1026024, rs3782499, rs2241529, rs1569198, rs3736228, rs556442, rs2302685, rs11054697, rs10743980 polymorphisms with PTB susceptibility. While, rs3782499 variant was associated with susceptibility to PTB under recessive model, and haplotype analysis showed that GA haplotype frequency was significantly increased in PTB patients. The rs3121310, rs2293303 polymorphisms were respectively associated with drug-induced liver injury (DILI), sputum smear-positive in PTB patients. The rs3782499 in gene was related to fever, leukopenia, and the rs1569198 in was linked to sputum smear-positive in PTB patients. In gene, rs3736228, rs556442 variants respectively affected the occurrence of DILI, fever, and gene rs2302685, rs10743980 variants respectively influenced the development of hypoproteinemia, sputum smear-positive in PTB patients. Our results revealed that WNT signaling pathway genes variation were not associated with the susceptibility to PTB, while , , , , , genetic variations might be closely related to the occurrence of several clinical characteristics of PTB patients.
本研究旨在评估 WNT 信号通路基因变异与中国汉族人群肺结核 (PTB) 易感性的关系。我们的研究对象包括 452 例 PTB 患者和 465 例正常对照，采用 SNPscan 技术对 WNT 信号通路中的 7 个基因（ 、 、 、 、 、 ）的 17 个 SNP 进行基因分型。我们发现 rs10088390、rs4736958、rs3242、rs752107、rs3121310、rs2293303、rs1798802、rs4135385、rs1026024、rs3782499、rs2241529、rs1569198、rs3736228、rs556442、rs2302685、rs11054697、rs10743980 多态性与 PTB 易感性无显著关系。然而，rs3782499 变异与隐性模型下的 PTB 易感性相关，单体型分析显示 PTB 患者中 GA 单体型频率显著增加。rs3121310、rs2293303 多态性分别与 PTB 患者的药物性肝损伤 (DILI)、痰涂片阳性相关。基因中的 rs3782499 与发热、白细胞减少有关，基因中的 rs1569198 与 PTB 患者的痰涂片阳性有关。在 基因中，rs3736228、rs556442 变异分别影响 DILI、发热的发生，基因 rs2302685、rs10743980 变异分别影响低蛋白血症、PTB 患者的痰涂片阳性的发生。我们的研究结果表明，WNT 信号通路基因变异与 PTB 的易感性无关，而 、 、 、 、 、 基因的遗传变异可能与 PTB 患者的几种临床特征的发生密切相关。
