Cancer Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Traditional Chinese Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
J Clin Lab Anal. 2023 Jan;37(1):e24824. doi: 10.1002/jcla.24824. Epub 2022 Dec 26.
Although many biomarkers for lung adenocarcinoma (LUAD) have been identified, their specificity and sensitivity remain unsatisfactory. Endothelial lipase gene (LIPG) plays an important role in a variety of cancers, but its role in lung adenocarcinoma remains unclear.
TCGA, GEO, K-M plotter, CIBERSORT, GSEA, HPA, and GDSC were used to analyze LIPG in LUAD. Data analysis was mainly achieved by R 4.0.3.
The expression of LIPG in LUAD tissues was higher than that in adjacent normal tissues, especially in women, patients aged >65 years, and those with lymph node metastasis. High expression predicted a poor prognosis. The results of enrichment analysis suggest that LIPG may exert profound effects on the development of LUAD through multiple stages of lipid metabolism and immune system regulation. In addition, LIPG expression was significantly correlated with the expression levels of multiple immune checkpoint genes and the abundance of multiple immune infiltrates, including the activated memory CD4 T cell, M1 macrophage, neutrophil, plasma cells, and T follicular helper (Tfh) cells in the LUAD microenvironment content. At the same time, patients with high LIPG expression respond well to a variety of antitumor drugs and have a low rate of drug resistance.
LIPG is a prognostic marker and is associated with lipid metabolism and immune infiltration in LUAD.
虽然已经鉴定出许多肺腺癌 (LUAD) 的生物标志物，但它们的特异性和灵敏度仍然不尽如人意。内皮脂肪酶基因 (LIPG) 在多种癌症中发挥重要作用，但在肺腺癌中的作用尚不清楚。
使用 TCGA、GEO、K-M plotter、CIBERSORT、GSEA、HPA 和 GDSC 分析 LUAD 中的 LIPG。数据分析主要通过 R 4.0.3 实现。
LIPG 在 LUAD 组织中的表达高于相邻正常组织，尤其是在女性、>65 岁的患者和有淋巴结转移的患者中。高表达预示着预后不良。富集分析的结果表明，LIPG 可能通过多种脂质代谢和免疫系统调节阶段对 LUAD 的发展产生深远影响。此外，LIPG 表达与多种免疫检查点基因的表达水平以及 LUAD 微环境中多种免疫浸润细胞的丰度显著相关，包括活化的记忆 CD4 T 细胞、M1 巨噬细胞、中性粒细胞、浆细胞和滤泡辅助 T 细胞 (Tfh) 细胞。同时，高 LIPG 表达的患者对多种抗肿瘤药物反应良好，耐药率低。
LIPG 是一种预后标志物，与 LUAD 中的脂质代谢和免疫浸润有关。
