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硝唑尼特成功治疗狒狒巴拉姆希阿米巴原虫肉芽肿性阿米巴脑炎。

Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline.

出版信息

Emerg Infect Dis. 2023 Jan;29(1):197-201. doi: 10.3201/eid2901.221531.

DOI:10.3201/eid2901.221531
PMID:36573629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9796214/
Abstract

A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline. Nitroxoline, which is a quinolone typically used to treat urinary tract infections, was identified in a screen for drugs with amebicidal activity against Balamuthia.

摘要

美国加利福尼亚州的一名患者患有罕见且通常致命的巴尔通体曼氏阿米巴原虫肉芽肿性阿米巴脑炎，在接受包括重新利用药物硝呋莫司在内的治疗方案后幸存下来。硝呋莫司是一种通常用于治疗尿路感染的喹诺酮类药物，它是在针对巴尔通体的杀阿米巴活性药物筛选中被发现的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4139/9796214/730d90ba384a/22-1531-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4139/9796214/03583c3aa845/22-1531-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4139/9796214/730d90ba384a/22-1531-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4139/9796214/03583c3aa845/22-1531-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4139/9796214/730d90ba384a/22-1531-F2.jpg

相似文献

[1]
Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline.

Emerg Infect Dis. 2023-1

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Repurposing Analysis of Nitroxoline (8-Hydroxy-5-nitroquinoline) as an Antichagasic Compound.

Pharmaceuticals (Basel). 2025-7-25

[2]
Brainstorm: A Case of Granulomatous Encephalitis.

J Assoc Med Microbiol Infect Dis Can. 2024-6-12

[3]
Fatal amoebic meningoencephalitis caused by in and first case report in .

Front Vet Sci. 2025-3-19

[4]
The role of plasma metagenomic sequencing in identification of Balamuthia mandrillaris encephalitis.

Acta Neuropathol Commun. 2025-3-13

[5]
Cyclic Peptide Natural Product Inspired Inhibitors of the Free-Living Amoeba .

J Nat Prod. 2025-2-28

[6]
Chitosan-based biomaterial delivery strategies for hepatocellular carcinoma.

Front Pharmacol. 2024-8-5

[7]
Modelling amoebic brain infection caused by Balamuthia mandrillaris using a human cerebral organoid.

PLoS Negl Trop Dis. 2024-6

[8]
Challenges and advances in the medical treatment of granulomatous amebic encephalitis.

Ther Adv Infect Dis. 2024-2-2

[9]
Drug repurposing for rare: progress and opportunities for the rare disease community.

Front Med (Lausanne). 2024-1-17

[10]
Primary amebic meningoencephalitis: a review of Naegleria fowleri and analysis of successfully treated cases.

Parasitol Res. 2024-1-6

本文引用的文献

[1]
Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics.

Nat Commun. 2022-3-30

[2]
Screening of the Open-Source Medicines for Malaria Venture Malaria and Pathogen Boxes To Discover Novel Compounds with Activity against Balamuthia mandrillaris.

Antimicrob Agents Chemother. 2020-4-21

[3]
Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.

N Engl J Med. 2019-6-13

[4]
Prospective Cohort Study of Next-Generation Sequencing as a Diagnostic Modality for Unexplained Encephalitis in Children.

J Pediatric Infect Dis Soc. 2020-7-13

[5]
Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid.

Genome Res. 2019-4-16

[6]
Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen .

mBio. 2018-10-30

[7]
The Epidemiology and Clinical Features of Balamuthia mandrillaris Disease in the United States, 1974-2016.

Clin Infect Dis. 2019-5-17

[8]
Transmission of Balamuthia mandrillaris by Organ Transplantation.

Clin Infect Dis. 2016-6-28

[9]
Diagnosing Balamuthia mandrillaris Encephalitis With Metagenomic Deep Sequencing.

Ann Neurol. 2015-11

[10]
Review of the literature and individual patients' data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections.

BMC Infect Dis. 2014-11-27

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