Ma Qingyuan, Minoshima Ken, Shoji Satoru
The University of Electro-Communications, 1-5-1, Chofugaoka, Chofu, Tokyo 182-8585, Japan.
J Phys Chem A. 2023 Jan 12;127(1):378-383. doi: 10.1021/acs.jpca.2c07289. Epub 2022 Dec 27.
Surface-enhanced Raman scattering (SERS) greatly improves molecule sensitivity compared with ordinary Raman spectroscopy. To excite and detect SERS efficiently, we fabricated glass-made microcapillary tubes decorated with silver nanoparticles inside them. The capillary tubes work as sample containers, where the required sample volume is in the order of a few nanoliters. The capillary tubes also play the role of optical waveguides. The tubes guide the excitation laser light through them so that the light illuminates whole silver nanoparticles inside the tubes at once. The tubes guide the SERS light to the tube end efficiently. The decoration of silver nanoparticles inside the tubes was performed by the silver mirror reaction. By making the tubes thinner and longer, highly sensitive SERS spectroscopy can be achieved. Our method would be a powerful tool for high-sensitivity molecule detection where the sample volume and concentration are extremely low.
与普通拉曼光谱相比，表面增强拉曼散射（SERS）极大地提高了分子灵敏度。为了有效地激发和检测SERS，我们制作了内部装饰有银纳米颗粒的玻璃微毛细管。毛细管用作样品容器，所需样品体积为几纳升量级。毛细管还起到光波导的作用。这些管子引导激发激光穿过它们，使光同时照亮管内的所有银纳米颗粒。这些管子将SERS光有效地引导到管端。管内银纳米颗粒的装饰通过银镜反应进行。通过使管子更细更长，可以实现高灵敏度的SERS光谱。我们的方法将成为一种强大的工具，用于在样品体积和浓度极低的情况下进行高灵敏度分子检测。
