Rheumatology department, CHU Clermont-Ferrand, 58, rue Montalembert, 63000 Clermont Ferrand, France.
Rheumatology department, Centre Hospitalier de Vichy, Vichy, France.
Joint Bone Spine. 2023 Mar;90(2):105500. doi: 10.1016/j.jbspin.2022.105500. Epub 2022 Nov 26.
Post-traumatic stress disorder (PTSD) may be a risk factor for the development of rheumatoid arthritis (RA). No data are available in spondyloarthritis (SpA). The aim of the present study was to investigate the frequency of traumatic events and PTSD in patients with SpA and its different phenotypes and to compare the results to patients with non inflammatory rheumatic disease and RA patients.
This was an observational, cross-sectional and bi-centric study. Participants were patients diagnosed with SpA, non-inflammatory rheumatic or autoimmune disease (controls), or RA. Traumatic events were identified by the brief trauma questionnaire (BTQ). PTSD was defined as the presence of a traumatic event and ≥4 symptoms on the short PTSD checklist scale.
Among 1389 participants, 510 patients were diagnosed with SpA (167 ankylosing spondylitis, 140 psoriatic arthritis, 130 non-radiographic-axial SpA, and 51 peripheral SpA), 365 with non-inflammatory rheumatic disease and 514 patients with RA. The frequency of trauma in SPA patients was 33.7%, of which 30.5% in AS, 30.7% in PsA, 37.7% in nr-axSpA and 41.2% in peripheral SpA (P=NS). The prevalence of PTSD in SPA patients was 4.9%, (of which 3.6% in AS, 2.9% in PsA, 6.2% in nr-axSpA and 7.8% in peripheral SpA [P=NS]) and was not significantly different from the controls (after IPTW 4.8% vs. 6.7%). The frequency of trauma and PTSD was also comparable between RA and controls and between SPA and RA.
Traumatic events and PTSD occurring prior to diagnosis is as rare in SpA as in non-inflammatory rheumatic diseases and RA.
创伤后应激障碍（PTSD）可能是类风湿关节炎（RA）发展的一个风险因素。在脊柱关节炎（SpA）中尚无相关数据。本研究旨在调查 SpA 及其不同表型患者中创伤事件和 PTSD 的发生频率，并将结果与非炎症性风湿性疾病和 RA 患者进行比较。
这是一项观察性、横断面和双中心研究。参与者为诊断为 SpA、非炎症性风湿性或自身免疫性疾病（对照组）或 RA 的患者。创伤事件通过简短创伤问卷（BTQ）确定。创伤后应激障碍定义为存在创伤事件和短创伤后应激障碍清单量表上≥4 个症状。
在 1389 名参与者中，510 名患者被诊断为 SpA（167 例强直性脊柱炎、140 例银屑病关节炎、130 例非放射学轴性 SpA 和 51 例外周 SpA）、365 名非炎症性风湿性疾病患者和 514 名 RA 患者。SpA 患者的创伤发生率为 33.7%，其中 AS 为 30.5%，PsA 为 30.7%，nr-axSpA 为 37.7%，外周 SpA 为 41.2%（P=NS）。SpA 患者 PTSD 的患病率为 4.9%（其中 AS 为 3.6%，PsA 为 2.9%，nr-axSpA 为 6.2%，外周 SpA 为 7.8%[P=NS]），与对照组无显著差异（经 IPTW 校正后为 4.8% vs. 6.7%）。RA 与对照组之间以及 SpA 与 RA 之间，创伤和 PTSD 的发生率也相似。
在 SpA 中，诊断前发生的创伤事件和 PTSD 与非炎症性风湿性疾病和 RA 一样罕见。
