两种新的苯丁烯类化合物来自卡萨姆生姜的根茎及其对 -葡萄糖苷酶的抑制活性。
Two new phenylbutenoids from the rhizomes of cassumunar ginger and their -glucosidase inhibitory activity.
机构信息
Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.
Vietnam National University, Ho Chi Minh City, Vietnam.
出版信息
Nat Prod Res. 2024 May;38(9):1545-1552. doi: 10.1080/14786419.2022.2157826. Epub 2022 Dec 28.
An extract from the rhizomes of Cassumunar ginger ( Roscoe). was found to have significant -glucosidase inhibitory activity with an IC value of 6.3 g/mL. Two new phenylbutenoids, cassudimin A () and cassumunol N (), and seven known compounds (-) were isolated. Their structures and relative configurations of two new compounds were elucidated based on spectra interpretation. Compounds -, - showed more potent -glucosidase inhibitory activity than a positive control, acarbose (IC = 168.0 M). Dehydrozingerone () exhibited the most potent -glucosidase inhibition with an IC value of 8.3 M. Compounds and were found in rhizomes for the first time.
从Cassumunar 姜（Roscoe）的根茎中提取到具有显著的 -葡萄糖苷酶抑制活性，IC 值为 6.3μg/mL。分离得到两种新的苯丁烯类化合物，casudimin A（()）和 cassumunol N（()），以及七种已知化合物（-）。根据光谱解析，确定了两种新化合物的结构和相对构型。化合物（-）表现出比阳性对照阿卡波糖（IC=168.0μM）更强的 -葡萄糖苷酶抑制活性。脱氢泽林酮（()）表现出最强的 -葡萄糖苷酶抑制活性，IC 值为 8.3μM。化合物（）和（）首次在姜根茎中发现。
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